Urinary N1, N12-diacetylspermine as a potential tumor biomarker for gastric and colorectal cancer

doi:10.3748/wjg.118185

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 7, 2026; 32(33): 118185
Published online Sep 7, 2026. doi: 10.3748/wjg.118185

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Figure 3 Diagnostic values of urinary N1, N12-diacetylspermine, serum carcinoembryonic antigen, and carbohydrate antigen 199 for gastric cancer and colorectal cancer, and their correlation. A: Receiver operating characteristic curves of urinary N1, N12-diacetylspermine (DiAcSpm), serum carcinoembryonic antigen (CEA) and carbohydrate antigen 199 for gastric cancer patients; B: Receiver operating characteristic curves of urinary DiAcSpm, serum CEA and carbohydrate antigen 199 for colorectal cancer patients; C: Correlation of urinary DiAcSpm and serum CEA levels in gastric cancer patients; D: Correlation of urinary DiAcSpm and serum CEA levels in colorectal cancer patients. TPR: True positive rate; AUC: Area under the curve; FPR: False positive rate; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; DiAcSpm: N1, N12-diacetylspermine.

Citation: Zheng HZ, Wang P, Zheng HJ, Wang ZQ, Li QX, Chen HW, Chen HQ, Lei QC. Urinary N1, N12-diacetylspermine as a potential tumor biomarker for gastric and colorectal cancer. World J Gastroenterol 2026; 32(33): 118185
URL: https://www.wjgnet.com/1007-9327/full/v32/i33/118185.htm
DOI: https://dx.doi.org/10.3748/wjg.118185

Zheng HZ, Wang P, Zheng HJ, Wang ZQ, Li QX, Chen HW, Chen HQ, Lei QC. Urinary N1, N12-diacetylspermine as a potential tumor biomarker for gastric and colorectal cancer. World J Gastroenterol 2026; 32(33): 118185 [DOI: 10.3748/wjg.118185]

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