Naringenin pretreatment attenuates hepatic ischemia-reperfusion injury by activating the PI3K-Akt signaling pathway

doi:10.3748/wjg.117979

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 7, 2026; 32(33): 117979
Published online Sep 7, 2026. doi: 10.3748/wjg.117979

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Figure 2 Naringenin attenuates hepatocyte apoptosis induced by hepatic ischemia-reperfusion injury. A: TUNEL staining showing apoptotic cells in liver tissues; B: Quantitative analysis of TUNEL-positive cells (n = 3); C: Western blots showing protein expression levels of Bax and Bcl-2; D and E: Densitometric quantification of Bax and Bcl-2 protein levels normalized to β-actin (n = 3). Scale bar: 100 μm. ^aP < 0.05 vs the Sham group, ^bP < 0.05 vs the ischemia-reperfusion injury group. NAR: Naringenin; IRI: Ischemia-reperfusion injury.

Citation: Lu JS, Liang HL, Chen DC, Pan H, Han T, Zhang WY, Fan M, Hou W, Shen ZY. Naringenin pretreatment attenuates hepatic ischemia-reperfusion injury by activating the PI3K-Akt signaling pathway. World J Gastroenterol 2026; 32(33): 117979
URL: https://www.wjgnet.com/1007-9327/full/v32/i33/117979.htm
DOI: https://dx.doi.org/10.3748/wjg.117979

Lu JS, Liang HL, Chen DC, Pan H, Han T, Zhang WY, Fan M, Hou W, Shen ZY. Naringenin pretreatment attenuates hepatic ischemia-reperfusion injury by activating the PI3K-Akt signaling pathway. World J Gastroenterol 2026; 32(33): 117979 [DOI: 10.3748/wjg.117979]

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