Naringenin pretreatment attenuates hepatic ischemia-reperfusion injury by activating the PI3K-Akt signaling pathway

Figure 1 Naringenin pretreatment attenuates hepatic ischemia-reperfusion injury in mice. A: Chemical structure of naringenin; B: Schematic timeline of naringenin intervention, ischemia-reperfusion injury model establishment and sample collection; C: Serum alanine aminotransferase activity (n = 6); D: Serum aspartate aminotransferase activity (n = 6); E: Hematoxylin and eosin staining of liver tissue; F: Suzuki pathological scores of liver injury based on hematoxylin and eosin staining (n = 6). Scale bar: 100 μm. ^aP < 0.05 vs the Sham group, ^bP < 0.05 vs the ischemia-reperfusion injury group, ^cP < 0.05 vs the ischemia-reperfusion injury + naringenin (50) group. NAR: Naringenin; ALT: Alanine aminotransferase; IRI: Ischemia-reperfusion injury; AST: Aspartate aminotransferase.