Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis

doi:10.3748/wjg.120450

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 28, 2026; 32(32): 120450
Published online Aug 28, 2026. doi: 10.3748/wjg.120450

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Figure 5 Network pharmacology and molecular docking analysis of extracts from Gleditsia sinensis thorns. A: Venn diagram illustrating the intersection of genes related to ulcerative colitis, extracts from Gleditsia sinensis thorns, and ferroptosis; B: “Target-Disease-Drug” interaction network; C: Protein-protein interaction network; D: Gene Ontology enrichment analysis showing the top 4 enriched terms in each module (ranked by adjusted P value); E: Kyoto Encyclopedia of Genes and Genomes pathway analysis; F: Molecular docking results of extracts from Gleditsia sinensis thorns with protein targets. BP: Biological process; CC: Cellular component; MF: Molecular function.

Citation: Zhuo ZY, Guo XY, Liu XM, Shang MM, Xue S, Peng L, Guo ZG. Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis. World J Gastroenterol 2026; 32(32): 120450
URL: https://www.wjgnet.com/1007-9327/full/v32/i32/120450.htm
DOI: https://dx.doi.org/10.3748/wjg.120450

Zhuo ZY, Guo XY, Liu XM, Shang MM, Xue S, Peng L, Guo ZG. Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis. World J Gastroenterol 2026; 32(32): 120450 [DOI: 10.3748/wjg.120450]

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