Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis

Figure 1 Extracts from Gleditsia sinensis thorns alleviates dextran sulfate sodium-induced colitis in mice. A: Changes in body weight; B: Disease activity index scores; C: Representative images of the colon from each group of mice; D: Colon length measurement; E: Hematoxylin and eosin staining of colon tissue sections (40 × and 200 × magnifications); F: Periodic acid-Schiff staining (40 × magnification); G: Histogram showing periodic acid-Schiff staining results; H: Enzyme-linked immunosorbent assay analysis of serum interleukin-6, interleukin-10, and tumor necrosis factor-α levels. Data are presented as mean ± SD (n = 6). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, and ^dP < 0.0001. DSS: Dextran sulfate sodium; EGST: Extracts from Gleditsia sinensis thorns; NS: Not significant.