P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis

doi:10.3748/wjg.119965

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 28, 2026; 32(32): 119965
Published online Aug 28, 2026. doi: 10.3748/wjg.119965

Table 2 P-element-induced wimpy testis-interacting RNA and gastric cancer metastasis

PiRNA	Biological process	Target area	Function	Ref.
piR-823	Upregulated	Peripheral blood	Regulating PINK1/Parkin-mediated mitochondrial autophagy	[66-68]
piR-48966	Upregulated	Gastric mucosa	Regulating JNK and ERK signaling pathways to promote EMT transformation	[70]
piR-49145	Upregulated	Gastric mucosa
piR-31335	Upregulated	Gastric mucosa
piR-47851	Upregulated	Gastric mucosa	Regulating MAPK1 protein levels to inhibit gastric cancer cell proliferation	[72]

EMT: Epithelial–mesenchymal transition; ERK: Extracellular signal-regulated kinase; JNK: Janus kinase; MAPK1: Mitogen-activated protein kinase 1; PINK1: PTEN induced kinase 1; PiRNA: P-element-induced wimpy testis-interacting RNA; PIWI: P-element-induced wimpy testis.

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Citation: Liu YW, Chen YK, Yan JY, Shen H, Mai FM, Kong ZH, Chen HL, Li LP, Liu WP, Gao Y, Zhang L. P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis. World J Gastroenterol 2026; 32(32): 119965
URL: https://www.wjgnet.com/1007-9327/full/v32/i32/119965.htm
DOI: https://dx.doi.org/10.3748/wjg.119965

Liu YW, Chen YK, Yan JY, Shen H, Mai FM, Kong ZH, Chen HL, Li LP, Liu WP, Gao Y, Zhang L. P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis. World J Gastroenterol 2026; 32(32): 119965 [DOI: 10.3748/wjg.119965]

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