Helicobacter pylori promotes gastric cancer progression by upregulating EPS8L3 to inhibit ferroptosis

Figure 7 Knockdown of epidermal growth factor receptor kinase substrate 8-like protein 3 inhibits tumor growth in in vivo experiments. A and B: Six nude mice per group were injected with equal amounts of control and sh-epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3) SGC-7901 cells; C and D: Tumor weight (C) and volume (D) profiles indicated that knockdown of EPS8L3 inhibited the proliferation of GC cells in vivo; E: Ki67 staining showing higher expression in the negative control group than in the sh-group in vivo, and hematoxylin and eosin staining showing tumor tissue morphology; F: Representative images of patient-derived gastric cancer organoids showing that growth inhibition by EPS8L3 knockdown is attenuated by Helicobacter pylori co-culture. Data are shown as the mean ± SD (n = 3). ^bP < 0.05. NC: Negative control.