Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases

doi:10.3748/wjg.v32.i32.119375

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 28, 2026; 32(32): 119375
Published online Aug 28, 2026. doi: 10.3748/wjg.v32.i32.119375

Table 2 Pathological data, n (%)/median (interquartile range)

Variable	TOS (n = 122)	LHS (n = 144)	P value
Tumor site			< 0.001
Right colon cancer	73 (59.8)	14 (9.7)
Left colon cancer	22 (18.0)	47 (32.6)
Rectal cancer	27 (10.2)	83 (57.6)
Maximum tumor size, cm
Primary lesion	4.00 (3.00, 6.00)	3.50 (2.50, 5.00)	0.003
Liver metastases	2.98 (1.57, 3.50)	2.98 (1.80, 3.00)	0.843
Differentiation of the primary lesion			0.677
Poor differentiation	28 (23.0)	30 (20.8)
Medium and high differentiation	94 (77.0)	114 (79.2)
Number of lymph nodes	16.00 (13.00, 19.00)	14.00 (11.00, 17.00)	0.001
Liver metastases number			0.936
< 3	113 (92.6)	133 (92.4)
> 3	9 (7.4)	11 (7.6)
pT stage			0.810
0-2	10 (8.2)	13 (9.0)
3-4	112 (91.8)	131 (91.0)
pN stage			0.736
0	45 (36.9)	47 (32.6)
1	54 (44.3)	70 (48.6)
2	23 (18.9)	27 (18.8)
KRAS gene			0.426
Wild-type	73 (59.8)	93 (64.6)
Mutant-type	49 (49.0)	51 (35.4)
BRAF gene			0.062
Wild-type	117 (95.9)	143 (99.3)
Mutant-type	5 (3.4)	1 (0.7)

TOS: Total open surgery; LHS: Laparoscopic hybrid surgery.

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Citation: Zhang TS, Zhu XM, Wen RB, Zhou LQ, Gong HF, Yu ED, Wang H, Li G, Zhou WP, Hao LQ, Yu GY, Zhang W. Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases. World J Gastroenterol 2026; 32(32): 119375
URL: https://www.wjgnet.com/1007-9327/full/v32/i32/119375.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i32.119375

Zhang TS, Zhu XM, Wen RB, Zhou LQ, Gong HF, Yu ED, Wang H, Li G, Zhou WP, Hao LQ, Yu GY, Zhang W. Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases. World J Gastroenterol 2026; 32(32): 119375 [DOI: 10.3748/wjg.v32.i32.119375]

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