Risk factors for low-level viremia in tenofovir disoproxil fumarate-treated chronic hepatitis B patients with advanced hepatic fibrosis/compensated cirrhosis

doi:10.3748/wjg.119706

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Aug 21, 2026; 32(31): 119706
Published online Aug 21, 2026. doi: 10.3748/wjg.119706

Table 2 Efficacy evaluation at week 48, n/total (%)

	48 weeks
	CVR	LLV	P value
HBV DNA decrease (Log₁₀ IU/mL)	4.5	5.2	< 0.050
HBeAg seroconversion	3/117 (2.6)	1/24 (4.2)	0.670
ALT 48 weeks	35.0	41.0	0.013
Normalized ALT	37/47 (78.7)	8/14 (57.1)	0.870
AST 48 weeks	30.0	30.0	0.128
Normalized AST	44/54 (81.5)	9/13 (69.2)	0.992
HBsAg loss, n (%)	0 (0.0)	1 (4.2)	> 0.999
LSM (kPa)	9.3	9.8	0.256
FIB-4	1.8	2.2	0.478
eGFR [mL/(minute × 1.73 m²)]	108.2	104.1	0.611
Creatinine (μmol/L)	69.0	73.2	0.777

CVR: Complete virological response; LLV: Low-level viremia; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HBsAg: Hepatitis B surface antigen; LSM: Liver stiffness measurement; FIB-4: Fibrosis-4 index; eGFR: Estimate glomerular filtration rate.

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Citation: Zhang RL, Zhang HY, Jia YY, Wang ZY, Liu F, Chen HS, Rao HY. Risk factors for low-level viremia in tenofovir disoproxil fumarate-treated chronic hepatitis B patients with advanced hepatic fibrosis/compensated cirrhosis. World J Gastroenterol 2026; 32(31): 119706
URL: https://www.wjgnet.com/1007-9327/full/v32/i31/119706.htm
DOI: https://dx.doi.org/10.3748/wjg.119706

Zhang RL, Zhang HY, Jia YY, Wang ZY, Liu F, Chen HS, Rao HY. Risk factors for low-level viremia in tenofovir disoproxil fumarate-treated chronic hepatitis B patients with advanced hepatic fibrosis/compensated cirrhosis. World J Gastroenterol 2026; 32(31): 119706 [DOI: 10.3748/wjg.119706]

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