Risk-stratified assessment of 180-day mortality in severe alcoholic hepatitis

doi:10.3748/wjg.118301

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 14, 2026; 32(30): 118301
Published online Aug 14, 2026. doi: 10.3748/wjg.118301

Table 1 Baseline characteristics of the study population

Variable	Overall (n = 1536)	Survived (n = 962)	Died (n = 574)	P value
MDF	51.00 (40.00-68.00)	45.50 (37.00-57.00)	64.00 (51.00-82.75)	< 0.001
MELD	16.00 (13.00-20.00)	14.00 (12.00-17.00)	19.00 (16.00-24.00)	< 0.001
Gender (male)	1495 (97.3)	934 (97.1)	561 (97.7)	0.515
Age (year)	48.00 (42.00-54.00)	48.00 (41.00-54.00)	48.00 (43.00-55.00)	0.086
ALB (g/L)	26.00 (22.00-29.00)	27.00 (23.00-30.00)	24.00 (20.00-28.00)	< 0.001
GLO (g/L)	29.00 (23.00-35.00)	30.00 (24.00-36.00)	27.00 (21.00-33.00)	< 0.001
ALT (U/L)	31.00 (21.00-47.00)	29.00 (20.00-42.00)	35.00 (23.00-54.00)	< 0.001
AST (U/L)	69.00 (46.00-111.00)	64.00 (44.00-102.75)	81.00 (52.00-124.00)	< 0.001
ALP (U/L)	136.00 (103.00-182.00)	139.00 (106.00-186.00)	130.00 (95.00-177.00)	0.008
GGT (U/L)	70.00 (32.00-166.00)	73.00 (33.00-165.00)	66.50 (30.00-167.50)	0.371
TBA (μmol/L)	131.00 (70.83-198.25)	127.75 (72.00-199.75)	136.00 (65.25-197.00)	0.952
PTS (second)	20.00 (18.00-23.00)	19.00 (18.00-21.75)	22.00 (20.00-26.00)	< 0.001
PTA (%)	37.00 (31.10-42.10)	38.90 (34.00-42.80)	33.50 (27.02-39.80)	< 0.001
TBIL (μmol/L)	165.40 (97.10-302.15)	129.05 (80.53-235.73)	241.35 (149.90-372.05)	< 0.001
INR	1.74 (1.60-1.99)	1.68 (1.58-1.88)	1.90 (1.68-2.23)	< 0.001
CRE (μmol/L)	83.00 (68.00-112.25)	76.00 (64.00-95.00)	107.00 (79.25-164.75)	< 0.001
TG (mmol/L)	0.90 (0.60-1.37)	0.95 (0.64-1.37)	0.82 (0.55-1.39)	0.001
CHE (U/L)	2067.00 (1504.75-2707.25)	2236.00 (1672.25-2842.75)	1762.00 (1312.00-2469.50)	< 0.001
CK (U/L)	67.00 (39.00-118.00)	69.00 (40.00-118.00)	65.00 (39.00-119.00)	0.979
FE (μmol/L)	19.80 (13.50-26.10)	20.00 (13.12-27.00)	19.50 (14.10-24.78)	0.388
AFP (ng/mL)	4.54 (2.77-8.00)	4.40 (2.81-7.84)	4.80 (2.73-8.88)	0.305
HGB (g/L)	97.00 (79.00-113.00)	99.00 (83.00-115.00)	92.70 (74.00-108.00)	< 0.001
PLT (× 10⁹/L)	71.00 (46.00-113.00)	72.50 (48.00-117.75)	68.20 (43.20-106.00)	0.017
SBP (yes)	473 (30.8)	238 (24.7)	235 (40.9)	< 0.001
Pulmonary infection (yes)	261 (17.0)	107 (11.1)	154 (26.8)	< 0.001
HRS (yes)	108 (7.0)	31 (3.2)	77 (13.4)	< 0.001
HE (yes)	373 (24.3)	139 (14.4)	234 (40.8)	< 0.001
Gastrointestinal bleeding (yes)	174 (11.3)	76 (7.9)	98 (17.1)	< 0.001
Glucocorticoid (yes)	96 (6.2)	41 (4.2)	55 (9.6)	< 0.001

Continuous variables are expressed as median (interquartile range) and categorical variables as n (%). MDF: Maddrey discriminant function; MELD: Model for end-stage liver disease; ALB: Albumin; GLO: Globulin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; TBA: Total bile acid; PTS: Prothrombin time seconds; PTA: Prothrombin activity; TBIL: Total bilirubin; INR: International normalized ratio; CRE: Creatinine; TG: Triglyceride; CHE: Cholinesterase; CK: Creatine kinase; FE: Iron; AFP: Alpha-fetoprotein; HGB: Hemoglobin; PLT: Platelet Count; SBP: Spontaneous bacterial peritonitis; HRS: Hepatorenal syndrome; HE: Hepatic encephalopathy.

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Citation: Xv YW, Ling J, Hao XG, Xu TJ, Tian H, Lv S, You SL, Zhu B. Risk-stratified assessment of 180-day mortality in severe alcoholic hepatitis. World J Gastroenterol 2026; 32(30): 118301
URL: https://www.wjgnet.com/1007-9327/full/v32/i30/118301.htm
DOI: https://dx.doi.org/10.3748/wjg.118301

Xv YW, Ling J, Hao XG, Xu TJ, Tian H, Lv S, You SL, Zhu B. Risk-stratified assessment of 180-day mortality in severe alcoholic hepatitis. World J Gastroenterol 2026; 32(30): 118301 [DOI: 10.3748/wjg.118301]

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