Misdiagnosis of alpha-gal syndrome as non-celiac gluten sensitivity or lactose intolerance: A diagnostic blind spot for clinicians

doi:10.3748/wjg.v32.i3.116350

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2026; 32(3): 116350
Published online Jan 21, 2026. doi: 10.3748/wjg.v32.i3.116350

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Figure 2 Immune-mediated pathogenesis of alpha-gal syndrome. Exposure of alpha-gal protein to the innate immune system (basophil) results in differentiation of naive T cell into Th2 cell. Eventual IgE production mediates symptom manifestation upon subsequent exposures to mammalian meat. IL: Interleukin.

Citation: Awosika A, Balaji P. Misdiagnosis of alpha-gal syndrome as non-celiac gluten sensitivity or lactose intolerance: A diagnostic blind spot for clinicians. World J Gastroenterol 2026; 32(3): 116350
URL: https://www.wjgnet.com/1007-9327/full/v32/i3/116350.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i3.116350

Awosika A, Balaji P. Misdiagnosis of alpha-gal syndrome as non-celiac gluten sensitivity or lactose intolerance: A diagnostic blind spot for clinicians. World J Gastroenterol 2026; 32(3): 116350 [PMID: 41640614 DOI: 10.3748/wjg.v32.i3.116350]

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