Misdiagnosis of alpha-gal syndrome as non-celiac gluten sensitivity or lactose intolerance: A diagnostic blind spot for clinicians

Table 3 Multiple organ-systems affected by alpha-gal syndrome and associated symptom manifestation[35]

Organ system	Common signs & symptoms	Approximately of patients affected (%)
Cutaneous/skin	Urticaria (hives), pruritus, angioedema (lips, eyelids, tongue, throat)	56-80
GI	Abdominal pain, nausea, vomiting, diarrhea, bloating	47-69
Respiratory	Wheezing, cough, shortness of breath, nasal congestion	15-30
Cardiovascular	Hypotension, dizziness, syncope (especially in anaphylaxis)	10-25
Systemic/anaphylaxis	Multisystem involvement (≥ 2 organ systems), generalized reactions	50-75

GI: Gastrointestinal.