Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity

doi:10.3748/wjg.v32.i3.114677

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2026; 32(3): 114677
Published online Jan 21, 2026. doi: 10.3748/wjg.v32.i3.114677

Table 3 Comparison of biomarkers between endoscopically active and inactive groups, median (interquartile range)

	Active	Inactive	P value
IBD
LRG, μg/mL	9.5 (7.25-11.75)	8.5 (6.75-11.2)	0.049^a
CRP, mg/dL	0.13 (0.06-0.33)	0.08 (0.04-0.23)	0.079
Hb, g/dL	13.9 (12.6-15.0)	13.7 (12.5-14.6)	0.403
Alb, g/dL	4.5 (4.3-4.7)	4.5 (4.4-4.8)	0.582
FC, mg/kg	217 (45-880)	47 (18-132)	< 0.001^a
UC
LRG, μg/mL	8.8 (7.5-11.2)	8.3 (6.7-11)	0.431
CRP, mg/dL	0.11 (0.05-0.23)	0.08 (0.05-0.21)	0.815
Hb, g/dL	14 (12.8-14.8)	13.3 (12.4-14.5)	0.221
Alb, g/dL	4.6 (4.3-4.8)	4.5 (4.4-4.7)	0.905
FC, mg/kg	102 (45-1336)	31 (10-79.5)	0.006^a
CD
LRG, μg/mL	11 (7-16.5)	8.6 (6.9-11.4)	0.012^a
CRP, mg/dL	0.2 (0.1-0.65)	0.09 (0.04-0.23)	0.019^a
Hb, g/dL	14.3 (12.2-15.5)	13.9 (12.8-14.6)	0.753
Alb, g/dL	4.5 (4.4-4.6)	4.5 (4.4-4.8)	0.269
FC, mg/kg	273 (55-626)	57.5 (27-167)	< 0.001^a

^aP < 0.05.

IBD: Inflammatory bowel disease; LRG: Leucine-rich α-2-glycoprotein; CRP: C-reactive protein; Hb: Hemoglobin; Alb: Albumin; FC: Fecal calprotectin; UC: Ulcerative colitis; CD: Crohn’s disease.

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Citation: Chen YC, Weng MT, Tsai FP, Chen ZC, Wu HY, Tung CC, Wang CY, Wei SC. Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity. World J Gastroenterol 2026; 32(3): 114677
URL: https://www.wjgnet.com/1007-9327/full/v32/i3/114677.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i3.114677

Chen YC, Weng MT, Tsai FP, Chen ZC, Wu HY, Tung CC, Wang CY, Wei SC. Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity. World J Gastroenterol 2026; 32(3): 114677 [PMID: 41640607 DOI: 10.3748/wjg.v32.i3.114677]

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