Is salvage treatment necessary after incomplete resection of rectal neuroendocrine tumors: A systematic review and meta-analysis

Table 3 Additional treatment modalities and follow-up duration, mean ± SD

Ref.	Tumor size (mm)	Additional treatment method							Follow-up duration (month)
		cEMR	mEMR	ESD	Hybrid ESD	EFTR	Surgery	APC
Cha et al[19]	5.2 ± 1.7		16				5		39.8 (range: 24.2-119.7)
Cha et al[20]	4.72		33				11		40.5 (range: 4.27-102.7)
Chatila et al[21]	8.6			10
Cheminel et al[22]	5 (range: 2-10)	19	15	44	1	7			24 (range: 2-216)
Cho et al[23]	5.8 ± 3.2
Choi et al[24]	5.5 ± 2.4								27.4 ± 16.5
Chung et al[25]	4.0 (range: 3.0-6.0)		3	2			4		35 (range: 24.4-48.8)
Dell’Unto et al[26]	6 (range: 1.0-16.0)								36
Duan et al[27]	8.4 (range: 7.5-10.8)								72
Heo et al[28]	6.1 ± 2.7								13 (range: 3-57)
Hwang et al[29]	8.6 ± 3.6								29.1 ± 31.3
Inoue et al[30]	5 (range: 3-13)								24.5 (range: 6-108)
Jeon et al[31]	8.9 ± 3.2	31							12
Ju et al[32]	4 (range: 2-6)	27		94
Kaneko et al[33]	6.4								61.6 (range: 12-150)
Kim et al[34]	5.0 (range: 1.0-10.0)								31 (range: 13-121)
Kim et al[35]									39.3
Kim et al[36]	4.46 ± 2.11								51.85 ± 22.92
Kim et al[37]	6.3 ± 3.1								19.3 (range: 0-122)
Kusuhara et al[38]	5 (range: 2-10)	2							27
Lee et al[39]	5.4 ± 3.1			21					39
Li et al[40]			38 (range: 10-110)	3			4		48.8 (range: 12-131)
Moon et al[14]	4.7 (range: 1-9)								25 (range: 12-43)
Moon et al[41]	5.7 ± 3.1	2							1
Nakamura et al[42]	5.6 ± 2.4		48.3	2			7	2	56.8 (range: 24-227.7)
Oh et al[43]
Park et al[44]	4.7 ± 2.7	1							71
Seo et al[45]			35.0 ± 37.6	16			7		19.0 (range: 1.2-57.5)
Sun et al[13]	9.0 ± 4.0
Sung et al[46]	7.0 ± 2.8			43					61.4 (range: 33.4-125.3)
Takita et al[47]	5.7						4	2	18.5 (range: 5-107)
Wang et al[48]	6.9 ± 3.3								31 (range: 6-97)
Zheng et al[49]	6.3 ± 2.9								28.3 (range: 6-98)
Zhuang et al[50]	6.5

cEMR: Conventional endoscopic mucosal resection; mEMR: Modified endoscopic mucosal resection; ESD: Endoscopic submucosal dissection; EFTR: Endoscopic full-thickness resection; APC: Argon plasma coagulation.