Perioperative SOX plus sintilimab vs P-SOX and CAPOX in advanced gastric cancer: A real-world comparison

Table 3 Results of univariate and multivariate Cox proportional hazards regression analyses

Variables	Univariate					Multivariate
	β	SE	Z	P value	HR (95%CI)	β	SE	Z	P value	HR (95%CI)
Age
≤ 60					1.00 (reference)					1.00 (reference)
> 60	-0.06	0.17	-0.33	0.739	0.95 (0.68-1.31)	0.22	0.18	1.22	0.222	1.24 (0.88-1.77)
ASA
1 + 2					1.00 (reference)					1.00 (reference)
3	-0.04	0.23	-0.15	0.878	0.97 (0.61-1.52)	-0.20	0.25	-0.81	0.420	0.82 (0.50-1.34)
Sex
Male					1.00 (reference)					1.00 (reference)
Female	-0.05	0.20	-0.26	0.797	0.95 (0.64-1.41)	0.14	0.22	0.64	0.522	1.15 (0.74-1.79)
Differentiation
Well					1.00 (reference)					1.00 (reference)
Moderate	0.64	0.25	2.57	0.010	1.89 (1.16-3.07)	0.29	0.28	1.04	0.298	1.33 (0.77-2.30)
Poorly	1.04	0.23	4.57	< 0.001	2.82 (1.81-4.41)	0.52	0.24	2.11	0.035	1.68 (1.04-2.71)
cT stage
2					1.00 (reference)					1.00 (reference)
3	0.11	0.21	0.53	0.598	1.12 (0.74-1.70)	-0.10	0.25	-0.41	0.680	0.90 (0.56-1.47)
4	0.70	0.23	3.04	0.002	2.02 (1.28-3.19)	-0.52	0.32	-1.62	0.105	0.60 (0.32-1.11)
cN stage
Negative					1.00 (reference)					1.00 (reference)
Positive	0.59	0.20	3.00	0.003	1.80 (1.23-2.64)	0.27	0.21	1.26	0.208	1.31 (0.86-2.00)
cTNM
II					1.00 (reference)					1.00 (reference)
IIIA	0.59	0.30	1.94	0.052	1.80 (0.99-3.25)	0.43	0.34	1.27	0.204	1.54 (0.79-2.99)
IIIB	1.10	0.21	5.19	< 0.001	3.00 (1.98-4.54)	1.13	0.24	4.71	< 0.001	3.09 (1.93-4.95)
IIIC	2.01	0.22	9.35	< 0.001	7.48 (4.91-11.40)	2.08	0.31	6.81	< 0.001	8.01 (4.40-14.59)
RECIST 1.1
Ineffective					1.00 (reference)					1.00 (reference)
Effective	-0.74	0.17	-4.43	< 0.001	0.48 (0.35-0.66)	-0.38	0.18	-2.12	0.034	0.68 (0.48-0.97)
Lauren
Diffuse					1.00 (reference)					1.00 (reference)
Mixed	-0.12	0.18	-0.64	0.520	0.89 (0.62-1.27)	0.02	0.20	0.07	0.941	1.02 (0.68-1.51)
Intestinal	-0.22	0.24	-0.92	0.356	0.80 (0.50-1.28)	-0.24	0.28	-0.85	0.397	0.79 (0.46-1.36)
Location
Upper					1.00 (reference)					1.00 (reference)
Middle	0.26	0.22	1.17	0.241	1.29 (0.84-1.99)	0.26	0.24	1.12	0.264	1.30 (0.82-2.07)
Lower	0.28	0.22	1.25	0.211	1.32 (0.86-2.03)	0.42	0.24	1.79	0.073	1.53 (0.96-2.43)
TRG
Ineffective					1.00 (reference)					1.00 (reference)
Effective	-0.84	0.17	-4.84	< 0.001	0.43 (0.31-0.60)	-0.73	0.20	-3.75	< 0.001	0.48 (0.33-0.70)
Tumor diameter
≤ 2					1.00 (reference)					1.00 (reference)
2-5	0.34	0.19	1.79	0.073	1.40 (0.97-2.03)	0.28	0.20	1.42	0.155	1.33 (0.90-1.97)
≥ 5	0.53	0.22	2.37	0.018	1.70 (1.10-2.63)	0.65	0.24	2.64	0.008	1.91 (1.18-3.08)

ASA: American Society of Anesthesiologists Score; RECIST: Response Evaluation Criteria in Solid Tumors; TRG: Tumor regression grade; cTNM: Clinical tumor-node-metastasis; HR: Hazards ratio; CI: Confidence interval.