Copyright: ©Author(s) 2026.
World J Gastroenterol. Aug 7, 2026; 32(29): 119809
Published online Aug 7, 2026. doi: 10.3748/wjg.119809
Published online Aug 7, 2026. doi: 10.3748/wjg.119809
Table 2 Side effects associated with three groups treatment, n (%)
| Variables | Total (n = 323) | P-SOX (n = 148) | SOX + XDL (n = 101) | CAPOX (n = 74) | Statistic | P value |
| Nausea and vomiting | -2 | 0.5691 | ||||
| 0 | 66 (20.43) | 36 (24.32) | 20 (19.80) | 10 (13.51) | ||
| 1 | 194 (60.06) | 84 (56.76) | 62 (61.39) | 48 (64.86) | ||
| 2 | 56 (17.34) | 26 (17.57) | 16 (15.84) | 14 (18.92) | ||
| 3 | 7 (2.17) | 2 (1.35) | 3 (2.97) | 2 (2.70) | ||
| Liver toxicity | -2 | 0.966 | ||||
| 0 | 275 (85.14) | 124 (83.78) | 88 (87.13) | 63 (85.14) | ||
| 1 | 44 (13.62) | 22 (14.86) | 12 (11.88) | 10 (13.51) | ||
| 2 | 4 (1.24) | 2 (1.35) | 1 (0.99) | 1 (1.35) | ||
| Alopecia | χ² = 17.08 | 0.002 | ||||
| 0 | 186 (57.59) | 76 (51.35) | 73 (72.28) | 37 (50.00) | ||
| 1 | 118 (36.53) | 58 (39.19) | 26 (25.74) | 34 (45.95) | ||
| 2 | 19 (5.88) | 14 (9.46) | 2 (1.98) | 3 (4.05) | ||
| Peripheral sensory neuropathy | -2 | 0.944 | ||||
| 0 | 160 (49.54) | 73 (49.32) | 47 (46.53) | 40 (54.05) | ||
| 1 | 133 (41.18) | 61 (41.22) | 43 (42.57) | 29 (39.19) | ||
| 2 | 26 (8.05) | 12 (8.11) | 9 (8.91) | 5 (6.76) | ||
| 3 | 4 (1.24) | 2 (1.35) | 2 (1.98) | 0 (0.00) | ||
| Fewer neutrophils | -2 | 0.362 | ||||
| 0 | 232 (71.83) | 112 (75.68) | 70 (69.31) | 50 (67.57) | ||
| 1 | 59 (18.27) | 24 (16.22) | 19 (18.81) | 16 (21.62) | ||
| 2 | 19 (5.88) | 5 (3.38) | 10 (9.90) | 4 (5.41) | ||
| 3 | 12 (3.72) | 6 (4.05) | 2 (1.98) | 4 (5.41) | ||
| 4 | 1 (0.31) | 1 (0.68) | 0 (0.00) | 0 (0.00) | ||
| Fewer white blood cells | -2 | 0.455 | ||||
| 0 | 209 (64.71) | 100 (67.57) | 63 (62.38) | 46 (62.16) | ||
| 1 | 73 (22.60) | 27 (18.24) | 29 (28.71) | 17 (22.97) | ||
| 2 | 28 (8.67) | 12 (8.11) | 8 (7.92) | 8 (10.81) | ||
| 3 | 9 (2.79) | 6 (4.05) | 1 (0.99) | 2 (2.70) | ||
| 4 | 4 (1.24) | 3 (2.03) | 0 (0.00) | 1 (1.35) | ||
| Fewer platelets | -2 | 0.319 | ||||
| 0 | 234 (72.45) | 110 (74.32) | 70 (69.31) | 54 (72.97) | ||
| 1 | 59 (18.27) | 24 (16.22) | 21 (20.79) | 14 (18.92) | ||
| 2 | 25 (7.74) | 12 (8.11) | 10 (9.90) | 3 (4.05) | ||
| 3 | 5 (1.55) | 2 (1.35) | 0 (0.00) | 3 (4.05) | ||
| Anemia | χ² = 6.44 | 0.376 | ||||
| 0 | 164 (50.77) | 79 (53.38) | 50 (49.50) | 35 (47.30) | ||
| 1 | 118 (36.53) | 52 (35.14) | 38 (37.62) | 28 (37.84) | ||
| 2 | 26 (8.05) | 12 (8.11) | 10 (9.90) | 4 (5.41) | ||
| 3 | 15 (4.64) | 5 (3.38) | 3 (2.97) | 7 (9.46) |
- Citation: Zhou DX, Jiang SW, Zhang CG, Cai BJ, Lv HD. Perioperative SOX plus sintilimab vs P-SOX and CAPOX in advanced gastric cancer: A real-world comparison. World J Gastroenterol 2026; 32(29): 119809
- URL: https://www.wjgnet.com/1007-9327/full/v32/i29/119809.htm
- DOI: https://dx.doi.org/10.3748/wjg.119809