Modified model incorporating sarcopenia and myosteatosis for predicting severe hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: Multicenter study

doi:10.3748/wjg.118090

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 7, 2026; 32(29): 118090
Published online Aug 7, 2026. doi: 10.3748/wjg.118090

Table 2 Univariate and multivariate Cox regression analyses of severe hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis

Characteristics	Univariate		Multivariate
Characteristics	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)	1.042 (1.018-1.067)	< 0.001	-	-
Gender (female/male)	0.609 (0.328-1.131)	0.116	-	-
Sarcopenia (yes/no)	2.598 (1.545-4.370)	< 0.001	2.722 (1.596-4.641)	< 0.001^a
Freiburg index of post-transjugular intrahepatic portosystemic shunt survival score	1.801 (1.349-2.405)	< 0.001	1.753 (1.266-2.428)	0.001^a
Prothrombin time (seconds)	1.023 (0.930-1.124)	0.644	-	-
Blood urea nitrogen (mmol/L)	1.050 (1.013-1.089)	0.008	1.002 (0.957-1.049)	0.932
White blood cell (10⁹/L)	0.941 (0.851-1.041)	0.237	-	-
Platelets (10⁹/L)	0.997 (0.992-1.001)	0.156	-	-
Lymphocyte (10⁹/L)	0.687 (0.424-1.112)	0.127	-	-
Hemoglobin (g/L)	1.003 (0.993-1.013)	0.542	-	-
Albumin (g/L)	0.968 (0.921-1.017)	0.2	-	-
Alanine aminotransferase (U/L)	1.004 (1.001-1.008)	0.022	1.004 (1.000-1.008)	0.085
Creatinine (μmol/L)	1.008 (1.003-1.013)	0.002	-	-
Total bilirubin (μmol/L)	1.015 (1.003-1.026)	0.013	-	-
Maximal transverse diameter of the right psoas muscle at the L3 level (cm)	0.594 (0.363-0.973)	0.038	-	-
Cross-sectional area of the right psoas muscle at the L3 level (cm²)	0.909 (0.802-1.031)	0.137	-	-
Mean muscle attenuation in HU of the right psoas muscle at the L3 level (HU)	0.964 (0.938-0.990)	0.007	-	-
Myosteatosis	2.245 (1.316-3.830)	0.003	1.921 (1.114-3.312)	0.019^a
L3_transversal psoas muscle thickness-to-height (mm/m)	0.907 (0.832-0.988)	0.025	-	-

^aP < 0.05 in the multivariable analysis.

Full candidate variables before stepwise selection included: Freiburg index of post-transjugular intrahepatic portosystemic shunt survival score, sarcopenia, blood urea nitrogen, alanine aminotransferase, and myosteatosis. HR: Hazard ratio; L3: Third lumbar vertebra.

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Citation: Zhang JQ, Yin L, Zhu YJ, Dong L, Hou CL, Tian SJ, Chen P, Huang XZ, Xu H, Chen ZY, Xu XJ, Zhou CZ, Cheng DL. Modified model incorporating sarcopenia and myosteatosis for predicting severe hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: Multicenter study. World J Gastroenterol 2026; 32(29): 118090
URL: https://www.wjgnet.com/1007-9327/full/v32/i29/118090.htm
DOI: https://dx.doi.org/10.3748/wjg.118090

Zhang JQ, Yin L, Zhu YJ, Dong L, Hou CL, Tian SJ, Chen P, Huang XZ, Xu H, Chen ZY, Xu XJ, Zhou CZ, Cheng DL. Modified model incorporating sarcopenia and myosteatosis for predicting severe hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: Multicenter study. World J Gastroenterol 2026; 32(29): 118090 [DOI: 10.3748/wjg.118090]

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