Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors

doi:10.3748/wjg.121267

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 28, 2026; 32(28): 121267
Published online Jul 28, 2026. doi: 10.3748/wjg.121267

Table 4 Diagnostic performance of the combined test across different disease groups

Disease group	Sensitivity (95%CI)	Specificity (95%CI)	PPV (95%CI)	NPV (95%CI)	LR+	LR-	AUC (95%CI)
Adenoma	65% (48.5%-78.8%)	60% (43.5%-75%)	61.9% (46.2%-76%)	63.2% (46.6%-77.8%)	1.63 (1.04-2.53)	0.58 (0.36-0.95)	0.662 (0.543-0.782)
CRC	87.5% (73%-95.8%)	60% (43.5%-75%)	68.6% (54.9%-80.2%)	82.8% (64.7%-93.2%)	2.19 (1.47-3.26)	0.21 (0.09-0.49)	0.866 (0.784-0.949)
Presence of intestinal lesions	76.3% (65.5%-84.7%)	60% (43.5%-75%)	79.2% (68.5%-87.2%)	55.8% (40.6%-70.2%)	1.91 (1.28-2.84)	0.4 (0.25-0.63)	0.764 (0.68-0.848)

CRC: Colorectal cancer; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio; AUC: Area under the receiver operating characteristic curve.

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Citation: Jing W, Qin L, Zhang XH, Pan F, Ren RR, Li Y, Zhang Y, Peng LH, Wang ZK, Zhang XL. Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors. World J Gastroenterol 2026; 32(28): 121267
URL: https://www.wjgnet.com/1007-9327/full/v32/i28/121267.htm
DOI: https://dx.doi.org/10.3748/wjg.121267

Jing W, Qin L, Zhang XH, Pan F, Ren RR, Li Y, Zhang Y, Peng LH, Wang ZK, Zhang XL. Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors. World J Gastroenterol 2026; 32(28): 121267 [DOI: 10.3748/wjg.121267]

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