Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors

doi:10.3748/wjg.121267

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 28, 2026; 32(28): 121267
Published online Jul 28, 2026. doi: 10.3748/wjg.121267

Table 3 Diagnostic performance of high-sensitivity quantitative fecal immunochemical test across different disease groups

Disease group	Sensitivity (95%CI)	Specificity (95%CI)	PPV (95%CI)	NPV (95%CI)	LR+	LR-	AUC (95%CI)
Adenoma	37.5% (22.9%-54.3%)	92.5% (79.7%-98.1%)	83.3% (60.5%-95.4%)	59.7% (46.6%-71.6%)	5 (1.9-13.2)	0.68 (0.5-0.9)	0.653 (0.532-0.774)
CRC	80% (64.4%-90.5%)	92.5% (79.7%-98.1%)	91.4% (77.2%-97.8%)	82.2% (67.9%-91.5%)	10.67 (3.55-32)	0.22 (0.12-0.4)	0.872 (0.786-0.958)
Presence of intestinal lesions	58.8% (47.1%-69.7%)	92.5% (79.7%-98.1%)	94% (83%-98.6%)	52.9% (40.6%-64.9%)	7.84 (2.6-23.6)	0.45 (0.34-0.59)	0.762 (0.677-0.848)

CRC: Colorectal cancer; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio; AUC: Area under the receiver operating characteristic curve.

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Citation: Jing W, Qin L, Zhang XH, Pan F, Ren RR, Li Y, Zhang Y, Peng LH, Wang ZK, Zhang XL. Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors. World J Gastroenterol 2026; 32(28): 121267
URL: https://www.wjgnet.com/1007-9327/full/v32/i28/121267.htm
DOI: https://dx.doi.org/10.3748/wjg.121267

Jing W, Qin L, Zhang XH, Pan F, Ren RR, Li Y, Zhang Y, Peng LH, Wang ZK, Zhang XL. Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors. World J Gastroenterol 2026; 32(28): 121267 [DOI: 10.3748/wjg.121267]

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