Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway

Figure 1 Hua-Zhuo-Jie-Du formula inhibited the tumorigenesis of colitis-associated colorectal cancer. A: Schematic diagram of the animal experiment operating procedures; B: Percentage change in body weight; C: Rate of survival; D: Disease activity index scores; E: Representative images of the colorectal tissues of the colitis-associated colorectal cancer mice; F: Colon lengths; G: Distribution of tumor sizes; H: Count of the colorectal tumors; I: Representative images for hematoxylin-eosin staining; J: Histological scores. Data are shown as the mean ± SD. ^bP < 0.01 vs control group. ^cP < 0.05 vs model group. ^dP < 0.01 vs model group. Control group (n = 12), model group (n = 7), low-dose Hua-Zhuo-Jie-Du formula group (n = 9), medium-dose Hua-Zhuo-Jie-Du formula group (n = 10), high-dose Hua-Zhuo-Jie-Du formula group (n = 10), and mesalazine group (n = 9). DSS: Dextran sodium sulfate; AOM: Azoxymethane; DAI: Disease activity index; HZJDF: Hua-Zhuo-Jie-Du formula; HZJDF-L: Low-dose Hua-Zhuo-Jie-Du formula; HZJDF-M: Medium-dose Hua-Zhuo-Jie-Du formula; HZJDF-H: High-dose Hua-Zhuo-Jie-Du formula.