Performance of computer-aided diagnosis for colorectal sessile serrated lesions: A systematic review and meta-analysis

doi:10.3748/wjg.118009

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 21, 2026; 32(27): 118009
Published online Jul 21, 2026. doi: 10.3748/wjg.118009

Table 2 Meta regression analysis for possible factors affecting the sensitivity of computer-aided diagnosis in distinguishing sessile serrated lesions from non-sessile serrated lesions and hyperplastic polyps

Factors	Sensitivity (SSL vs non-SSLs)				Sensitivity (SSL vs HPs)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)
Publication time (vs year 2020)	0.67	1.77 (0.13-23.36)			0.48	2.49 (0.20-31.49)
Multicenter (vs single center)	0.10	0.09 (0.01-1.61)			0.06	0.03 (0.00-1.19)	0.14	0.10 (0.00-2.09)
Europe (vs Asia)	0.67	1.77 (0.13-23.36)			0.64	1.97 (0.12-33.01)
Prospective (vs retrospective)	0.67	1.77 (0.13-23.36)			0.33	3.40 (0.29-39.44)
Olympus (vs Fujifilm)	0.83	0.66 (0.02-27.83)			0.11	6.84 (0.65-72.26)
Criteria 2019 (vs 2010)	0.06	11.15 (0.90-138.8)	0.07	2.97 (0.92-9.53)	0.19	4.55 (0.47-43.74)
ICA (vs ODA)	< 0.01	16.22 (7.73-34.05)	< 0.01	14.13 (6.89-29.01)	0.18	5.28 (0.47-59.22)
Real time (vs nonreal time)	0.10	0.09 (0.01-1.61)			0.58	0.41 (0.02-9.53)
Images (vs videos)	0.67	0.57 (0.04-7.47)			0.64	0.51 (0.03-8.48)
NBI (vs non-NBI)	0.47	2.68 (0.18-39.61)			0.01	10.80 (1.97-59.33)	0.02	7.27 (1.40-37.63)

SSL: Sessile serrated lesion; HPs: Hyperplastic polyps; OR: Odds ratio; CI: Confidence interval; ICA: Image classification algorithms; ODA: Object detection algorithm; NBI: Narrow band imaging.

Full Size Table

Citation: Zhang S, Wang SH, Zhao YD, Wei JH, Sui XY, Li X, Zhang HW, Huang ZY, Wang CL, Hu H, Zhang J, Li ZS, Zhao SB, Bai Y. Performance of computer-aided diagnosis for colorectal sessile serrated lesions: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(27): 118009
URL: https://www.wjgnet.com/1007-9327/full/v32/i27/118009.htm
DOI: https://dx.doi.org/10.3748/wjg.118009

Zhang S, Wang SH, Zhao YD, Wei JH, Sui XY, Li X, Zhang HW, Huang ZY, Wang CL, Hu H, Zhang J, Li ZS, Zhao SB, Bai Y. Performance of computer-aided diagnosis for colorectal sessile serrated lesions: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(27): 118009 [DOI: 10.3748/wjg.118009]

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