Non-alcoholic fatty liver disease fibrosis score is a useful tool for carotid atherosclerosis screening in patients with obstructive sleep apnea

Table 4 Metabolic and hepatic characterization of patients with obstructive sleep apnea according to carotid atherosclerosis, n (%)

Features	OSA without carotid plaque (n = 67)	OSA with carotid plaque (n = 45)	P value
Body mass index ≥ 30	28 (41.8)	24 (53.3)	0.251
HOMA-IR score ≥ 3	41 (61.2)	28 (62.2)	1.000
Dyslipidemia	29 (43.3)	24 (53.3)	0.338
Metabolic syndrome	17 (25.4)	8 (17.8)	0.367
Simple steatosis by OWLiver™ test	20 (29.9)	15 (33.3)	0.836
Steatohepatitis by OWLiver™ test	37 (55.2)	19 (42.2)	0.247
FLI (a.u.)	66.58 ± 27.09	68.88 ± 29.99	0.486
FLI ≥ 60	41 (61.2)	32 (71.1)	0.317
FSI (a.u.)	0.34 ± 0.25	0.43 ± 0.26	0.035
FSI ≥ 0.23	37 (55.2)	36 (80.0)	0.009
NFS (a.u.)	-1.54 ± 0.95	-0.75 ± 1.10	> 0.001
NFS < -1.455	39 (58.2)	11 (24.4)	> 0.001
FIB-4 (a.u.)	1.12 ± 0.38	1.57 ± 1.05	> 0.001
FIB-4 < 1.3	50 (74.6)	21 (46.7)	0.002
HFS (a.u.)	0.06 ± 0.08	0.12 ± 0.18	0.005
HFS < 0.12	55 (82.1)	34 (75.6)	0.477

HOMA-IR: Homeostatic model assessment-insulin resistance; a.u.: Arbitrary units; FLI: Fatty liver index; FSI: Framingham steatosis index; FIB-4: Fibrosis-4; NFS: Non-alcoholic fatty liver disease fibrosis score; HFS: Hepamet fibrosis score.