High cyclin-dependent kinase 5 expression promotes tumor progression in gastric neuroendocrine carcinoma

Table 2 Univariable and multivariable Cox regression analyses of risk factors for overall survival in patients with gastric neuroendocrine carcinoma

Clinicopathologic parameters	Univariate model		Multivariate model
	HR (95%CI)	P value	HR (95%CI)	P value
Age, years
≤ 65	Reference
> 65	0.97 (0.49-1.94)	0.939
Gender
Female	Reference
Male	0.91 (0.49-1.72)	0.778
Tumor location
Upper	Reference
Middle	0.39 (0.12-1.30)	0.126
Lower	0.87 (0.44-1.70)	0.680
Mix	1.13 (0.15-8.44)	0.902
Tumor resection
Total	Reference
Partial1	1.06 (0.55-2.04)	0.871
Tumor length, cm
< 5	Reference
≥ 5	2.42 (1.22-4.79)	0.011
pT stage
T1-T3	Reference		Reference
T4	2.29 (1.24-4.25)	0.008	1.64 (0.83-3.22)	0.154
pN stage
N0	Reference		Reference
N+	2.47 (1.09-5.60)	0.031	1.82 (0.76-4.36)	0.181
Nerve invasion
No	Reference
Yes	2.22 (0.98-5.01)	0.056
Vascular invasion
No	Reference
Yes	1.56 (0.77-3.17)	0.222
CDK5
Low	Reference		Reference
High	2.66 (1.33-5.32)	0.006	2.13 (1.03-4.41)	0.041

¹Distal or proximal gastrectomy.

CDK5: Cyclin-dependent kinase 5; HR: Hazard ratio; CI: Confidence interval.