Clinical assessment of malnutrition among patients with alcoholic liver cirrhosis: A single-center study in Southern China

doi:10.3748/wjg.v32.i26.118957

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 14, 2026; 32(26): 118957
Published online Jul 14, 2026. doi: 10.3748/wjg.v32.i26.118957

Table 1 Patients’ overall characteristics, n (%)/median (interquartile range)

Variables	HCs (n = 83)	HBV-C (n = 103)	ALC (n = 249)	P value
Age (year)	50.00 (35.00-62.50)	53.00 (47.00-58.50)	53.00 (46.00-60.00)	0.122
Height (m)	1.68 (1.63-1.73)	1.68 (1.62-1.71)	1.68 (1.64-1.71)	0.769
Weight (kg)	65.00 (54.15-75.25)	64.00 (59.60-70.65)	64.00 (57.90-71.00)	0.910
BMI (kg/m²)	23.24 (19.74-25.88)	23.32 (20.99-25.84)	23.03 (20.98-25.06)	0.835
WBC (× 10⁹/L)	5.89 (5.12-7.29)	3.98 (2.96-4.99)^a	4.85 (3.54-6.40)^a^,^b	< 0.001
RBC (× 10¹²/L)	4.72 (3.89-5.08)	3.72 (3.08-4.22)^a	3.44 (2.84-4.04)^a^,^b	< 0.001
Hb (g/L)	137.00 (118.50-150.00)	109.00 (83.50-131.00)^a	101.00 (76.00-119.00)^a^,^b	< 0.001
MCV (fL)	89.80 (85.05-92.35)	89.30 (79.25-94.15)	88.70 (77.70-96.10)	0.987
PLT (× 10⁹/L)	231.00 (189.00-288.00)	77.00 (51.50-120.00)^a	104.00 (72.00-155.00)^a^,^b	< 0.001
NEUT	0.56 (0.51-0.65)	0.60 (0.51-0.69)	0.60 (0.49-0.68)	0.383
LYMPH	0.32 (0.25-0.37)	0.25 (0.18-0.33)^a	0.27 (0.17-0.34)^a	0.002
MONO	0.08 (0.06-0.09)	0.10 (0.08-0.12)^a	0.11 (0.09-0.13)^a	< 0.001
NLR	1.79 (1.39-2.54)	2.42 (1.52-3.89)^a	2.18 (1.38-3.88)	0.031
PLR	118.60 (97.19-164.77)	88.31 (65.12-128.85)^a	86.37 (67.07-117.62)^a	< 0.001
SII	419.67 (299.52-635.94)	220.73 (113.15-350.83)^a	256.81 (133.52-387.29)^a	< 0.001
SIRI	0.91 (0.60-1.24)	0.87 (0.47-1.84)	0.99 (0.64-2.06)	0.185
AST (U/L)	20.00 (16.50-27.00)	35.00 (26.00-56.50)^a	42.00 (29.00-65.00)^a	< 0.001
ALT (U/L)	18.00 (12.50-30.00)	28.00 (18.00-38.50)^a	25.00 (17.00-37.00)^a	0.002
AST/ALT	1.06 (0.76-1.52)	1.43 (1.09-1.79)^a	1.74 (1.21-2.44)^a^,^b	< 0.001
GGT (U/L)	22.00 (16.00-42.00)	50.00 (22.50-91.50)^a	85.00 (45.00-196.25)^a^,^b	< 0.001
ALP (U/L)	67.00 (56.50-81.00)	97.00 (77.50-136.50)^a	120.00 (85.75-174.75)^a^,^b	< 0.001
ALB (g/L)	41.85 (39.00-45.50)	35.30 (31.90-39.70)^a	34.10 (29.40-38.40)^a	< 0.001
TBIL (μmol/L)	9.45 (6.53-13.65)	15.20 (11.15-20.20)^a	20.80 (12.20-40.80)^a^,^b	< 0.001
DBILI (μmol/L)	2.20 (1.50-3.10)	4.80 (3.50-9.35)^a	6.90 (3.60-17.50)^a	< 0.001
IBILI (μmol/L)	6.80 (3.45-10.05)	9.60 (7.00-12.95)^a	10.40 (7.20-17.60)^a	< 0.001
BUN (mmol/L)	5.07 (4.28-5.97)	5.09 (3.97-6.67)	4.69 (3.40-6.36)	0.074
Cr (μmol/L)	67.00 (57.50-83.00)	71.00 (58.50-81.00)	65.00 (55.00-81.00)	0.215
GLU (mmol/L)	5.16 (4.66-6.29)	5.85 (4.83-8.18)^a	5.84 (4.71-7.98)^a	0.010
CHOL (mmol/L)	4.68 (4.08-5.54)	3.85 (3.34-4.60)^a	3.79 (2.84-4.67)^a	< 0.001
TG (mmol/L)	1.26 (0.83-1.92)	0.91 (0.68-1.40)^a	1.03 (0.75-1.44)	0.002
HDL (mmol/L)	1.02 (0.87-1.18)	0.93 (0.68-1.14)^a	0.89 (0.68-1.14)^a	0.008
LDL (mmol/L)	2.83 (2.20-3.54)	2.15 (1.61-2.71)^a	2.06 (1.45-2.73)^a	< 0.001
UA (μmol/L)	349.00 (277.00-426.00)	311.00 (240.50-388.00)	360.50 (291.75-452.25)^b	0.001
TyG	8.59 (8.11-9.20)	8.48 (8.01-8.97)	8.50 (8.09-9.06)	0.323
PT (second)	13.10 (12.78-13.80)	15.50 (14.75-17.00)^a	16.00 (14.80-18.05)^a	< 0.001
PTA (%)	101.50 (94.00-111.00)	73.00 (62.00-80.50)^a	68.00 (53.00-81.00)^a	< 0.001
INR	0.99 (0.95-1.06)	1.23 (1.14-1.37)^a	1.27 (1.15-1.49)^a	< 0.001
Ascites				0.082
No or mild		79 (78.22)	162 (67.22)
Clinically overt ascites		22 (21.78)	79 (32.78)
CTP				< 0.001
A		51 (49.51)	108 (43.37)
B/C		52 (50.49)	141 (56.63)

^aP < 0.05 for alcoholic liver cirrhosis or hepatitis B virus-related cirrhosis vs healthy controls.

^bP < 0.05 for alcoholic liver cirrhosis vs hepatitis B virus-related cirrhosis.

ALC: Alcoholic liver cirrhosis; HBV-C: Hepatitis B virus-related cirrhosis; HCs: Healthy controls; BMI: Body mass index; WBC: White blood cell; RBC: Red blood cell; Hb: Hemoglobin; MCV: Mean corpuscular volume; PLT: Platelet; NEUT: Neutrophil; LYMPH: Lymphocyte; MONO: Monocyte; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SII: Systemic immune-inflammation index; SIRI: Systemic inflammatory response index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; ALB: Albumin; TBIL: Total bilirubin; DBILI: Direct bilirubin; IBILI: Indirect bilirubin; BUN: Blood urea nitrogen; Cr: Creatinine; GLU: Glucose; CHOL: Cholesterol; TG: Triglycerides; HDL: High density lipoprotein; LDL: Low density lipoprotein; UA: Uric acid; TyG: Triglyceride-glucose index; PT: Prothrombin time; PTA: Prothrombin activity; INR: International normalized ratio; CTP: Child-Pugh classification.

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Citation: Wu XQ, Liu YY, Yu HS, Abassa KK, Pan LL, Ke BL, Guo YW. Clinical assessment of malnutrition among patients with alcoholic liver cirrhosis: A single-center study in Southern China. World J Gastroenterol 2026; 32(26): 118957
URL: https://www.wjgnet.com/1007-9327/full/v32/i26/118957.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i26.118957

Wu XQ, Liu YY, Yu HS, Abassa KK, Pan LL, Ke BL, Guo YW. Clinical assessment of malnutrition among patients with alcoholic liver cirrhosis: A single-center study in Southern China. World J Gastroenterol 2026; 32(26): 118957 [DOI: 10.3748/wjg.v32.i26.118957]

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