Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort

doi:10.3748/wjg.118595

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 26

This Article

(47)

(71)

(0)

(389)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 14, 2026; 32(26): 118595
Published online Jul 14, 2026. doi: 10.3748/wjg.118595

Table 5 Association between difficult-to-treat characteristics at diagnosis and fatigue in a cohort of patients with Crohn’s disease: A multiple linear regression analysis

Characteristics	Total scores		General fatigue		Physical fatigue		Mental fatigue		Reduced activity		Reduced motivation
Characteristics	Coefficient (95%CI)	P value	Coefficient (95%CI)	P value	Coefficient (95%CI)	P value	Coefficient (95%CI)	P value	Coefficient (95%CI)	P value	Coefficient (95%CI)	P value
Fistula	-	-	-	-	-	-	-	-	-	-	-	-
Number of biologics	-	-	-	-	-	-	-	-	-	-	-	-
Disease activity	8.535 (4.225-12.846)	0.000	2.041 (0.878-3.205)	0.001	2.314 (1.080-3.549)	0.000	-	-	1.765 (0.830-2.699)	0.000	1.326 (0367-2.284)	0.007
Surgical history	-	-	-	-	-	-	-	-	1.765 (0.830-2.699)	0.012	-	-
Disease duration	-	-	-	-	-	-	-	-	-	-	-	-
A2	-	-	2.677 (0.393-4.962)	0.022	-	-	-	-	-	-	-	-
A3	-	-	3.119 (0.557-5.681)	0.017	-	-	-	-	2.111 (0.054-4.167)	0.044	2.131 (0.022-4.241)	0.022
L3 + L4		-	-	-	-	-	-	-	1.647 (0.033-3.262)	0.046	-	-
L2 + L4	-	-	-	-	-	-	-	-	-	-	-	-
L1 + L4	-	-	-	-	-	-	-	-	-	-	-	-
L2	-	-	-	-	-	-	-	-	-	-	-	-
L3	-	-	-	-	-	-	-	-	-	-	-	-
L4	-	-	-	-	-	-	-	-	-	-	-	-
B2	-	-	-	-	-	-	-	-	-	-	-	-
B3	-	-	-	-	-	-	-	-	-	-	-	-
B2 + B3	-	-	-	-	-	-	-	-	-	-	-	-
Total	n = 175		n = 175		n = 175		n = 175		n = 175		n = 175

Variable in the model: (1) Fistula; (2) Number of biologics or small molecule with different mechanism; (3) Disease activity; (4) Surgery history; (5) Disease duration; (6) B2; (7) B3; (8) A2; (9) A3; (10) L2; (11) L3; (12) L4; (13) L1 + L4; (14) L2 + L4; and (15) L3 + L4. Fistula: Simple or complex anal fistula. Number of biologics or small molecule with different mechanism: (1) Anti-tumor necrosis factor (infliximab, adalimumab); (2) Integrin receptor antagonist (vedolizumab); (3) Interleukin antagonist (ustekinumab); and (4) Janus kinase inhibitor (tofacitinib)[18].

Full Size Table

Citation: Wu Z, Huang ZW, Cao ZJ, Sun Y, Zhao XX, Xu WF, Chen SL, Zhang Y, Zhao SL. Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort. World J Gastroenterol 2026; 32(26): 118595
URL: https://www.wjgnet.com/1007-9327/full/v32/i26/118595.htm
DOI: https://dx.doi.org/10.3748/wjg.118595

Wu Z, Huang ZW, Cao ZJ, Sun Y, Zhao XX, Xu WF, Chen SL, Zhang Y, Zhao SL. Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort. World J Gastroenterol 2026; 32(26): 118595 [DOI: 10.3748/wjg.118595]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.