Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort

doi:10.3748/wjg.118595

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World Journal of Gastroenterology

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1007-9327

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 14, 2026; 32(26): 118595
Published online Jul 14, 2026. doi: 10.3748/wjg.118595

Table 3 Results of a multivariable logistic regression analysis examining risk factors for difficult-to-treat Crohn’s disease

Characteristics	Exp(B)	Lower 95%CI	Upper 95%CI	P value
Age at diagnosis
A2	1.652	0.342	7.985	0.532
A3	0.869	0.145	5.205	0.878
Disease behavior
B2	0.566	0.239	1.339	0.196
B3	0.822	0.19	3.546	0.792
B2 + B3	3.502	0.753	16.277	0.110
Disease location
L2	0.510	0.083	3.120	0.466
L3	1.863	0.797	4.352	0.151
L4	0.000	0.000	0.000	0.999
L1 + L4	6.032	0.954	38.135	0.056
L2 + L4	0.398	0.02	7.912	0.546
L3 + L4	2.965	0.744	11.808	0.123
IL-5	2.656	1.421	4.964	0.002
IL-10	1.255	1.011	1.558	0.04
Hemoglobin	1.023	1.002	1.045	0.035
Disease duration	1.096	1.016	1.182	0.018
Enteral nutrition
Total enteral nutrition	1.591	0.534	4.742	0.404
Partial enteral nutrition	2.858	1.165	7.014	0.022
Disease activity	0.621	0.271	1.423	0.261

The model adjusted for disease activity and was based on data from 168 patients (from an initial cohort of 175; 7 exclusions due to incomplete data). IL: Interleukin.

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Citation: Wu Z, Huang ZW, Cao ZJ, Sun Y, Zhao XX, Xu WF, Chen SL, Zhang Y, Zhao SL. Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort. World J Gastroenterol 2026; 32(26): 118595
URL: https://www.wjgnet.com/1007-9327/full/v32/i26/118595.htm
DOI: https://dx.doi.org/10.3748/wjg.118595

Wu Z, Huang ZW, Cao ZJ, Sun Y, Zhao XX, Xu WF, Chen SL, Zhang Y, Zhao SL. Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort. World J Gastroenterol 2026; 32(26): 118595 [DOI: 10.3748/wjg.118595]

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