Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort

doi:10.3748/wjg.118595

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World Journal of Gastroenterology

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1007-9327

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 14, 2026; 32(26): 118595
Published online Jul 14, 2026. doi: 10.3748/wjg.118595

Table 2 Multivariable logistic regression analysis of risk factors for difficult-to-treat Crohn’s disease

Characteristics	Exp(B)	Lower 95%CI	Upper 95%CI	P value
Age at diagnosis
A2	1.568	0.328	7.500	0.574
A3	0.796	0.136	4.674	0.801
Disease behavior
B2	0.560	0.238	1.321	0.186
B3	0.908	0.213	3.874	0.896
B2 + B3	3.042	0.676	13.692	0.147
Disease location
L2	0.473	0.079	2.843	0.414
L3	1.762	0.765	4.060	0.183
L4	0.000	0.000	0.000	0.999
L1 + L4	6.443	1.011	41.081	0.049
L2 + L4	0.344	0.018	6.387	0.474
L3 + L4	2.882	0.743	11.187	0.126
IL-5	2.715	1.457	5.058	0.002
IL-10	1.234	1.005	1.515	0.045
Hemoglobin	1.025	1.005	1.047	0.016
Disease duration	1.097	1.017	1.182	0.016
Enteral nutrition
Total enteral nutrition	1.538	0.52	4.542	0.436
Partial enteral nutrition	2.940	1.209	7.153	0.017

The analysis was conducted on data from 168 Crohn’s disease patients (seven patients were excluded due to incomplete data). IL: Interleukin.

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Citation: Wu Z, Huang ZW, Cao ZJ, Sun Y, Zhao XX, Xu WF, Chen SL, Zhang Y, Zhao SL. Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort. World J Gastroenterol 2026; 32(26): 118595
URL: https://www.wjgnet.com/1007-9327/full/v32/i26/118595.htm
DOI: https://dx.doi.org/10.3748/wjg.118595

Wu Z, Huang ZW, Cao ZJ, Sun Y, Zhao XX, Xu WF, Chen SL, Zhang Y, Zhao SL. Risk factors and fatigue in difficult-to-treat Crohn’s disease: A cross-sectional study of a Chinese cohort. World J Gastroenterol 2026; 32(26): 118595 [DOI: 10.3748/wjg.118595]

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