Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm

doi:10.3748/wjg.119364

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2026; 32(25): 119364
Published online Jul 7, 2026. doi: 10.3748/wjg.119364

Table 3 Univariate and multivariate Cox analyses for early recurrence of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm in the training cohort

Parameters	N = 390, n (%)	Univariate Cox analysis			Multivariate Cox analysis
Parameters	N = 390, n (%)	β	HR (95%CI)	P value	β	HR (95%CI)	P value
Age (> 60 years)	82 (21.0)	0.267	1.306 (0.870-1.961)	0.197
Sex (male)	336 (86.2)	-0.018	0.983 (0.605-1.596)	0.944
Smoking (yes)	128 (32.8)	-0.006	0.994 (0.694-1.424)	0.975
Drinking (yes)	78 (20.0)	-0.033	0.968 (0.631-1.484)	0.881
Diabetes (yes)	37 (9.5)	0.430	1.537 (0.924-2.556)	0.097
Hypertension (yes)	46 (11.8)	-0.005	0.995 (0.590-1.676)	0.984
Cirrhosis (yes)	258 (66.2)	0.208	1.231 (0.856-1.772)	0.262
Anti-HCV (positive)	4 (1.0)	-0.182	0.834 (0.117-5.963)	0.856
HBV-DNA (copy/mL; > 1000)	180 (46.2)	0.064	1.066 (0.762-1.493)	0.708
HBeAg (positive)	53 (13.6)	0.184	1.202 (0.761-1.897)	0.430
AFP (ng/mL; > 400)	102 (26.2)	-0.010	0.990 (0.674-1.455)	0.960
Diameter (cm; > 3)	197 (50.5)	0.499	1.647 (1.171-2.319)	0.004	0.450	1.569 (1.109-2.221)	0.011
Number (multiple)	71 (18.2)	0.693	2.001 (1.366-2.930)	< 0.001	0.641	1.899 (1.293-2.788)	0.001
Differentiation (medium-poor)	314 (80.5)	0.208	1.232 (0.787-1.929)	0.362
Vascular invasion (yes)	41 (10.5)	0.381	1.464 (0.892-2.405)	0.132
MVI (yes)	90 (23.1)	0.649	1.914 (1.322-2.770)	0.001	0.578	1.782 (1.222-2.597)	0.003
Child-Pugh grade (B)	9 (2.3)	-0.035	0.965 (0.307-3.031)	0.952
IRS (high)	190 (48.7)	0.581	1.789 (1.273-2.514)	0.001	0.581	1.787 (1.269-2.516)	0.001
Staging systems
BCLC stage (B-C)	77 (19.7)	0.614	1.848 (1.266-2.697)	0.001
AJCC-TNM, 8^th (II-III)	98 (25.1)	0.516	1.676 (1.172-2.396)	0.005
CNLC (II-III)	69 (17.7)	0.583	1.791 (1.210-2.652)	0.004

HCV: Hepatitis C virus; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; AFP: Alpha-fetoprotein; MVI: Microvascular invasion; IRS: Inflammation-related score; BCLC: Barcelona Clinic Liver Cancer; AJCC-TNM: American Joint Committee on Cancer Tumor-Node-Metastasis; CNLC: China Liver Cancer.

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Citation: Dai TX, Li J, Li H, Wang GY. Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm. World J Gastroenterol 2026; 32(25): 119364
URL: https://www.wjgnet.com/1007-9327/full/v32/i25/119364.htm
DOI: https://dx.doi.org/10.3748/wjg.119364

Dai TX, Li J, Li H, Wang GY. Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm. World J Gastroenterol 2026; 32(25): 119364 [DOI: 10.3748/wjg.119364]

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