Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm

doi:10.3748/wjg.119364

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 7, 2026; 32(25): 119364
Published online Jul 7, 2026. doi: 10.3748/wjg.119364

Table 2 Comparison of clinicopathological information and inflammatory indices between the training and validation cohorts

Parameter	Training cohort, n = 390	Validation cohort, n = 260	P value
Age (> 60 years)	82 (21.0)	73 (28.1)	0.039
Sex (male)	336 (86.2)	233 (89.6)	0.191
Smoking (yes)	128 (32.8)	101 (38.8)	0.115
Drinking (yes)	78 (20.0)	66 (25.4)	0.105
Diabetes (yes)	37 (9.5)	20 (7.7)	0.428
Hypertension (yes)	46 (11.8)	32 (12.3)	0.844
Cirrhosis (yes)	258 (66.2)	177 (68.1)	0.610
Anti-HCV (positive)	4 (1.0)	1 (0.4)	0.653
HBV-DNA (copy/mL; > 1000)	180 (46.2)	120 (46.2)	1.000
HBeAg (positive)	53 (13.6)	33 (12.7)	0.741
AFP (ng/mL; > 400)	102 (26.2)	68 (26.2)	1.000
Diameter (cm; > 3)	197 (50.5)	118 (45.4)	0.200
Number (multiple)	71 (18.2)	63 (24.2)	0.063
Differentiation (medium-poor)	314 (80.5)	213 (81.9)	0.653
Vascular invasion (yes)	41 (10.5)	27 (10.4)	0.958
MVI (yes)	90 (23.1)	83 (31.9)	0.012
Child-Pugh grade (B)	9 (2.3)	12 (4.6)	0.103
BCLC stage (B-C)	77 (19.7)	51 (19.6)	0.968
AJCC-TNM, 8^th (II-III)	98 (25.1)	85 (32.7)	0.036
CNLC (II-III)	69 (17.7)	46 (17.7)	1.000
Early recurrence (yes)	136 (34.9)	86 (33.1)	0.636
NLR (> 1.71)	207 (53.1)	134 (51.5)	0.700
PLR (> 71.66)	270 (69.2)	177 (68.1)	0.756
LMR (> 4.83)	126 (32.3)	72 (27.7)	0.210
GPR (> 0.31)	181 (46.4)	148 (56.9)	0.009
PNI (> 49.65)	195 (50.0)	124 (47.7)	0.564
SII (> 323.51)	141 (36.2)	93 (35.8)	0.920
SIRI (> 0.99)	113 (29.0)	86 (33.1)	0.266
APRI (> 0.27)	132 (33.8)	107 (41.2)	0.058
ANRI (> 12.81)	148 (37.9)	115 (44.2)	0.110
ALRI (> 22.16)	136 (34.9)	116 (44.6)	0.012
ALBI (> -2.58)	124 (31.8)	91 (35.0)	0.395
FIB-4 (> 1.67)	220 (56.4)	163 (62.7)	0.111
S-index (> 0.14)	232 (59.5)	173 (66.5)	0.069
AAR (> 0.87)	242 (62.1)	149 (57.3)	0.226

The data were showed as n (%). HCV: Hepatitis C virus; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; AFP: Alpha-fetoprotein; MVI: Microvascular invasion; BCLC: Barcelona Clinic Liver Cancer; AJCC-TNM: American Joint Committee on Cancer Tumor-Node-Metastasis; CNLC: China Liver Cancer; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; GPR: Gamma-glutamyl transpeptidase-to-platelet ratio; PNI: Prognostic nutritional index; SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; ALBI: Albumin-bilirubin index; ALRI: Aspartate aminotransferase to lymphocyte ratio index; ANRI: Aspartate aminotransferase to neutrophil ratio index; APRI: Aspartate aminotransferase to platelet ratio index; FIB-4: Fibrosis index based on four factors; AAR: Aspartate aminotransferase to alanine aminotransferase ratio.

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Citation: Dai TX, Li J, Li H, Wang GY. Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm. World J Gastroenterol 2026; 32(25): 119364
URL: https://www.wjgnet.com/1007-9327/full/v32/i25/119364.htm
DOI: https://dx.doi.org/10.3748/wjg.119364

Dai TX, Li J, Li H, Wang GY. Novel inflammation-based model for postoperative early recurrence prediction of hepatitis B virus-related hepatocellular carcinoma ≤ 5 cm. World J Gastroenterol 2026; 32(25): 119364 [DOI: 10.3748/wjg.119364]

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