Baseline multimodal clinical-radiomics-pathomics model predicts mucosal healing in Crohn’s disease after infliximab therapy

Table 4 Results of all models predictive ability for predicting mucosal healing in Crohn’s disease

Models		AUC (95%CI)	Accuracy	Sensitivity	Specificity	PPV	NPV
Model 1	Train	0.921 (0.860-0.982)	0.859	0.925	0.774	0.841	0.889
	Test	0.799 (0.641-0.957)	0.774	0.778	0.769	0.824	0.714
Model 2	Train	0.724 (0.616-0.833)	0.690	0.650	0.742	0.765	0.622
	Test	0.669 (0.486-0.851)	0.677	0.667	0.692	0.750	0.600
Model 3	Train	0.931 (0.874-0.989)	0.873	0.875	0.871	0.897	0.844
	Test	0.863 (0.703-1.000)	0.742	0.611	0.923	0.917	0.632
Model 4	Train	0.773 (0.656-0.889)	0.747	0.725	0.774	0.806	0.895
	Test	0.731 (0.533-0.928)	0.645	0.611	0.692	0.733	0.615
Model 5	Train	0.910 (0.845-0.975)	0.845	0.925	0.742	0.822	0.885
	Test	0.872 (0.744-1.000)	0.807	0.778	0.846	0.875	0.733
Model 6	Train	0.980 (0.955-1.000)	0.944	0.975	0.903	0.929	0.966
	Test	0.915 (0.808-1.000)	0.774	0.833	0.692	0.790	0.750
Model 7	Train	0.860 (0.778-0.942)	0.803	0.925	0.871	0.882	0.896
	Test	0.812 (0.668-0.956)	0.774	0.944	0.769	0.824	0.833
Model A	Train	0.873 (0.803-0.944)	0.819	0.805	0.846	0.912	0.659
	Test	0.827 (0.716-0.938)	0.706	0.618	0.882	0.913	0.647
Model B	Train	0.756 (0.674-0.839)	0.675	0.714	0.615	0.722	0.522
	Test	0.636 (0.518-0.754)	0.618	0.412	0.882	0.618	0.429
Model C	Train	0.951 (0.915-0.988)	0.922	0.961	0.846	0.925	0.917
	Test	0.866 (0.748-0.984)	0.804	0.882	0.647	0.833	0.733
Model D	Train	0.739 (0.636-0.842)	0.776	0.896	0.744	0.793	0.724
	Test	0.687 (0.501-0.873)	0.765	0.882	0.765	0.790	0.692
Model E	Train	0.919 (0.870-0.968)	0.836	0.792	0.923	0.953	0.784
	Test	0.819 (0.682-0.957)	0.720	0.697	0.765	0.852	0.667
Model F	Train	0.951 (0.916-0.987)	0.897	0.896	0.897	0.945	0.814
	Test	0.922 (0.843-1.000)	0.880	0.909	0.824	0.909	0.824
Model G	Train	0.950 (0.912-0.988)	0.871	0.844	0.923	0.956	0.750
	Test	0.908 (0.822-0.994)	0.820	0.788	0.882	0.929	0.682

Ileal: Model 1-radiomics, model 2-clinical, model 3-pathomics, model 4-radiomics and clinical, model 5-pathomics and clinical, model 6-radiomics and pathomics, model 7 combined. Ileocolonic: Model A-radiomics, model B-clinical, model C-pathomics, model D-radiomics and clinical, model E-pathomics and clinical, model F-radiomics and pathomics, model G-combined. CI: Confidence interval; AUC: Area under the curve; NPV: Negative predictive value; PPV: Positive predictive value.