Baseline multimodal clinical-radiomics-pathomics model predicts mucosal healing in Crohn’s disease after infliximab therapy

Table 3 Positive results of univariate and multivariate logistic regression analysis for predicting mucosal healing in Crohn’s disease

Features	Ileal						Ileocolonic
	Univariate			Multivariate			Univariate			Multivariate
	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value
Gender	0.250	0.064-0.983	0.047	0.079	0.006-1.061	0.055	1.908	0.834-4.364	0.126
Age at CD diagnosis	1.029	0.989-1.071	0.155				1.009	0.968-1.053	0.662
Disease duration (day)	1.000	0.997-1.003	0.875				1.001	0.998-1.003	0.669
CRP at baseline	1.002	0.971-1.034	0.896				1.018	1.000-1.036	0.051	1.010	0.987-1.032	0.397
ESR at baseline	0.972	0.931-1.015	0.195				1.000	0.981-1.019	0.997
WBC at baseline	0.826	0.650-1.049	0.117				1.078	0.904-1.285	0.404
Alb at baseline	0.880	0.785-0.986	0.023	0.893	0.754-1.058	0.041	0.997	0.934-1.065	0.931
FC at baseline	0.999	0.998-1.000	0.142				0.999	0.998-1.000	0.015	0.999	0.998-1.001	0.031
Perianal involvement	0.443	0.170-1.159	0.095	0.247	0.051-1.187	0.081	1.352	0.617-2.965	0.451
Smoking status at diagnosis	1.037	0.214-5.016	0.964				828993669.358	0.000	1.000
Previous steroids or immunomodulators use	3.491	1.096-11.124	0.104				1.485	0.559-3.948	0.711
Montreal behavior	1.058	0.343-3.262	0.752				3.187	0.369-27.570	0.566
HBI at baseline	0.799	0.642-0.966	0.059	0.935	0.629-1.389	0.740	1.090	0.942-1.262	0.247
Rad score				1.173	1.010-1.363	0.037				3.820	1.541-9.473	0.004
Pat score				6.135	2.282-16.492	< 0.001				3.992	2.198-7.250	< 0.001

OR: Odds ratio; CI: Confidence interval; CD: Crohn’s disease; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; Alb: Albumin; FC: Fecal calprotectin; WBC: White blood cell; HBI: Harvey-Bradshaw index.