FOLH1 as a novel biomarker for risk stratification in gastric intestinal metaplasia

Figure 8 Prognostic value of FOLH1 for risk stratification in gastric intestinal metaplasia. A: Kaplan-Meier progression-free survival analysis by FOLH1 expression. Cumulative probability of progression-free survival stratified by FOLH1 integrated optical density levels. Patients with low FOLH1 expression had a significantly higher rate of malignant transformation during 5-year follow-up than the high-expression group (Log-rank P < 0.0001); B: Multivariate Cox regression hazard ratios for gastric intestinal metaplasia (GIM) progression. Forest plot illustrating the independent risk of progression. Low FOLH1 expression is a dominant independent risk factor [hazard ratio (HR) = 65.5, P < 0.001] when adjusted for age, gender, and clinical diagnosis; C: Multivariate Cox regression incorporating operative link on GIM (OLGIM) staging. Forest plot evaluating the protective effect of continuous FOLH1 levels (HR = 0.92 per unit increase, P = 0.002) alongside clinical risk factors. Severe GIM remained a significant risk factor (HR = 4.07, P = 0.044), while OLGIM types II and III did not show independent statistical significance in this model. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. F: Female; M: Male; GIM: Gastric intestinal metaplasia; OLGIM: Operative link on gastric intestinal metaplasia.