Calcium-dependent signaling protein family member S100A11 promotes liver and adipose lipid accumulation through fibroblast growth factor 21

doi:10.3748/wjg.118597

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 7, 2026; 32(25): 118597
Published online Jul 7, 2026. doi: 10.3748/wjg.118597

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Figure 9 Fibroblast growth factor 21 neutralization partially reverses S100A11-induced lipid accumulation in vitro. All data are presented as mean ± SE. n = 6 biological replicates. Statistical analysis was performed using unpaired two-tailed Student’s t-test: ^aP < 0.05 vs recombinant adenoviruses encoding green fluorescent protein, ^bP < 0.05 vs recombinant adenoviruses encoding S100A11_IgG. A: Triglyceride content in AML12; B: Cholesterol content in AML12; C and D: Expression levels of brown adipose tissue and white adipose tissue related genes in 3T3-L1 cells. FGF21: Fibroblast growth factor 21; AD-GFP: Recombinant adenoviruses encoding green fluorescent protein; AD-SA/AD-S100A11: Recombinant adenoviruses encoding S100A11; UCP1: Uncoupling protein 1; PGC1α: Peroxisome proliferator-activated receptor gamma coactivator 1-α; PRDM16: PR domain containing 16.

Citation: Zhang QQ, Lu XQ, Shang BZ, Liu LC, Lu ET, Li HY, Xia MM, Jin YX, Zhang WZ, Zhang Y, Han JY, Li Y. Calcium-dependent signaling protein family member S100A11 promotes liver and adipose lipid accumulation through fibroblast growth factor 21. World J Gastroenterol 2026; 32(25): 118597
URL: https://www.wjgnet.com/1007-9327/full/v32/i25/118597.htm
DOI: https://dx.doi.org/10.3748/wjg.118597

Zhang QQ, Lu XQ, Shang BZ, Liu LC, Lu ET, Li HY, Xia MM, Jin YX, Zhang WZ, Zhang Y, Han JY, Li Y. Calcium-dependent signaling protein family member S100A11 promotes liver and adipose lipid accumulation through fibroblast growth factor 21. World J Gastroenterol 2026; 32(25): 118597 [DOI: 10.3748/wjg.118597]

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