Calcium-dependent signaling protein family member S100A11 promotes liver and adipose lipid accumulation through fibroblast growth factor 21

Figure 7 Fibroblast growth factor 21 neutralization partially reverses S100A11-induced lipid accumulation in vivo. All data are presented as mean ± SE. n = 6 biological replicates. Statistical analysis was performed using unpaired two-tailed Student’s t-test: ^aP < 0.05 vs wild type_IgG, ^bP < 0.05 vs transgenic _IgG. Five-week-old male wild type and transgenic mice were fed a high-fat diet for 12 weeks, during which they were injected with either a fibroblast growth factor 21-neutralizing antibody or its isotype control every 3 days. A: Schematic diagram of the experimental design; B: Body weight; C: Body fat percentage; D: Hepatic triglyceride content. FGF21: Fibroblast growth factor 21; WT: Wild type; BW: Body weight.