Calcium-dependent signaling protein family member S100A11 promotes liver and adipose lipid accumulation through fibroblast growth factor 21

Figure 6 Fibroblast growth factor 21 levels in tissues and plasma of male S100A11-hTg mice. All data are presented as means ± SE. n = 5 or 6 mice/group. Statistical analysis was performed using one-way analysis of variance, P values were adjusted for multiple testing using the Bonferroni correction: ^aP < 0.05 vs normal-chow diet wild type, ^bP < 0.05 vs high-fat diet wild type. Five-week-old male S100A11-hTg mice and littermate control mice were fed normal-chow diet or high-fat diet for 12 weeks. A: Plasma fibroblast growth factor 21 (FGF21) level at 17 weeks of age; B: Liver FGF21 mRNA expression level at 17 weeks of age; C: Fgf21 mRNA expression level in brown adipose tissue at 17 weeks of age; D: Fgf21 mRNA expression level in epididymal white adipose tissue of mice at 17 weeks of age; E: Protein interaction network of human S100A11. Protein-protein interaction network of human S100A11 generated by the STRING database (Homo sapiens). High-confidence interactors are shown (minimum required interaction score: 0.700). Key interaction partners are labeled, including members of the S100 protein family, annexin family proteins, the receptor for advanced glycation end products, and the multifunctional nucleolar protein nucleolin. FGF21: Fibroblast growth factor 21; NCD: Normal-chow diet; HFD: High-fat diet; WT: Wild type.