Curcumin nanoparticles mitigate early inflammation in severe acute pancreatitis by modulating peritoneal macrophage polarization via Nrf2/HO-1 pathway activation

Figure 4 Curcumin nanoparticles activate nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway in peritoneal macrophages in vivo. A: The expression levels of t nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) mRNA, with the internal reference gene GAPDH normalized; B: Representative immunoblots of Nrf2 and HO-1 proteins with corresponding quantitative grayscale analysis. The data were expressed as mean ± SD (n = 6 rats in each group). ^aP < 0.05 vs sham, ^bP < 0.05 vs severe acute pancreatitis. Cur-NPs: Curcumin nanoparticles; SAP: Severe acute pancreatitis; iNOS: Inducible nitric oxide synthase; HO-1: Heme oxygenase-1; Nrf2: Nuclear factor erythroid 2-related factor 2.