Curcumin nanoparticles mitigate early inflammation in severe acute pancreatitis by modulating peritoneal macrophage polarization via Nrf2/HO-1 pathway activation

Figure 2 The therapeutic effect of curcumin nanoparticles in a rat model of severe acute pancreatitis. A: Representative photomicrographs of pancreatic tissue sections (hematoxylin and eosin staining); B: Histopathological scoring of pancreatic tissues for evaluating the severity of edema, inflammation, and necrosis. Orange arrows indicate areas of necrosis, inflammatory cell infiltration, and hemorrhage; C: The expression level of serum amylase; D: The expression level of serum lipase; E: The expression level of serum pro-inflammatory cytokine tumor necrosis factor-α; F: The expression level of serum interleukin-1β. The data were expressed as mean ± SD (n = 6 rats in each group). ^aP < 0.05 vs sham, ^bP < 0.05 vs severe acute pancreatitis. Cur-NPs: Curcumin nanoparticles; SAP: Severe acute pancreatitis.