Acute liver injury after transcatheter arterial chemoembolization in patients with hepatitis B virus-related intermediate or advanced hepatocellular carcinoma stages

Table 2 Risk factors for post-transcatheter arterial chemoembolization acute liver injury in patients with hepatitis B virus-related hepatocellular carcinoma

Clinical factor	Univariate logistic regression			Multivariate logistic regression
	OR	95%CI	P value	OR	95%CI	P value
Sex	0.710	0.291-1.731	0.451
Age	0.984	0.953-1.015	0.312
Child-Pugh stage	0.409	0.191-0.875	0.021	0.320	0.136-0.701	0.006
BCLC	0.967	0.516-1.813	0.917
Weight (kg)	1.007	0.978-1.037	0.654
Height (m)	0.663	0.009-50.362	0.852
Duration of TACE	1.004	0.987-1.021	0.671
Number of TACE	2.245	1.188-4.244	0.013	2.131	1.078-4.259	0.030
Tumor diameter (mm)	1.006	0.998-1.014	0.121
Tumor number	0.781	0.411-1.484	0.451
PNI	1.009	0.999-1.02	0.083
CONUT	0.838	0.698-1.006	0.058
GNRI	1.027	0.998-1.058	0.067
TC (mmol/L)	1.125	0.849-1.492	0.411
AFP (ng/mL)	1.000	1.000-1.000	0.429
HBsAg (log10 IU/mL)	0.934	0.753-1.158	0.532
HBeAg (log10 IU/mL)	1.437	0.743-2.78	0.281
HBV DNA (< 20) (IU/mL)	Reference	Reference	Reference	Reference	Reference	Reference
HBV DNA (20-2000) (IU/mL)	2.566	1.236-5.328	0.011	2.568	1.207-5.573	0.015
HBV DNA (> 2000) (IU/mL)	2.982	1.288-6.909	0.011	2.843	1.166-7.052	0.022
ALT (U/L)	1.004	0.992-1.017	0.468
AST (U/L)	1.000	0.994-1.006	0.998
GGT (U/L)	1.000	0.999-1.002	0.623
TBIL (μmol/L)	1.003	0.974-1.033	0.823
ALB (g/L)	1.047	0.993-1.105	0.09
PT (seconds)	0.812	0.651-1.012	0.063
INR	0.152	0.016-1.428	0.099
NLR	1.027	0.959-1.099	0.443
WBC (× 109/L)	1.048	0.928-1.184	0.449
NE (× 109/L)	1.052	0.911-1.214	0.491
LYM (× 109/L)	1.204	0.735-1.972	0.461
PLT (× 109/L)	1.000	0.996-1.004	0.845

OR: Odds ratio; CI: Confidence interval; TACE: Transcatheter arterial chemoembolization; BCLC: Barcelona clinic liver cancer staging system; PNI: Prognostic nutritional index; CONUT: Controlling nutritional status; GNRI: Geriatric nutritional risk index; TC: Total cholesterol; AFP: Alpha-fetoprotein; HBsAg: Hepatitis B surface antigens; HBeAg: Hepatitis B e antigens; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; AST: Aspartate transaminase; GGT: Gamma-glutamyl transpeptidase; TBIL: Total bilirubin; ALB: Albumin; PT: Prothrombin time; INR: International normalized ratio; NLR: Neutrophils to lymphocytes ratio; WBC: White blood cell; NE: Neutrophil; LYM: Lymphocyte; PLT: Platelet.