Differential metabolites facilitate metabolic dysfunction-associated fatty liver disease malignancy via immune evasion and M2-polarized macrophages

doi:10.3748/wjg.117849

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 28, 2026; 32(24): 117849
Published online Jun 28, 2026. doi: 10.3748/wjg.117849

Table 1 Dynamic levels of lipids, enzymes and alpha-fetoprotein in the sera of the metabolic dysfunction-associated fatty liver disease rats

Group	n	Tch (mmol/L)	TG (mmol/L)	HDL (mmol/L)	LDL (mmol/L)	ALT (IU/L)	AST (IU/L)	AFP (ng/mL)
NC	6	1.32 ± 0.49	0.61 ± 0.19	2.20 ± 0.42	0.38 ± 0.09	14.75 ± 3.02	15.88 ± 3.29	0.88 ± 0.09
MAFLD	12	2.72 ± 0.46^a	0.99 ± 0.41^a	0.67 ± 0.20^a	1.19 ± 0.40^a	44.61 ± 14.34^a	44.86 ± 9.90^a	0.96 ± 0.30
MASH	11	3.76 ± 0.54^a	1.78 ± 0.25^a	1.36 ± 0.17^a	0.65 ± 0.09^a	62.19 ± 29.79^a	44.46 ± 9.25^a	1.46 ± 0.41
LC	13	3.29 ± 0.24^a	1.81 ± 0.27^a	1.17 ± 0.13^a	0.75 ± 0.09^a	55.75 ± 26.89^a	61.99 ± 18.21^a	1.60 ± 0.42
HCC	6	3.50 ± 0.60^a	1.22 ± 0.21^a	1.47 ± 0.11^a	0.63 ± 0.05^a	46.08 ± 13.39^a	47.91 ± 21.22^a	1.83 ± 0.54^a
F value		21.341	13.014	52.861	32.857	8.128	11.600	8.015
P value		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

^aP < 0.001 vs normal control group.

NC: Normal control; MAFLD: Metabolic dysfunction-associated fatty liver disease; MASH: Metabolic dysfunction-associated steatohepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; Tch: Total cholesterol; TG: Triglyceride; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; ALT: Alanine aminotransferase; AST: Aspartate transaminase; AFP: Alpha-fetoprotein.

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Citation: Yang J, Sai WL, Xia XX, Tang H, Xu M, Xie Q, Yao DF, Yao M. Differential metabolites facilitate metabolic dysfunction-associated fatty liver disease malignancy via immune evasion and M2-polarized macrophages. World J Gastroenterol 2026; 32(24): 117849
URL: https://www.wjgnet.com/1007-9327/full/v32/i24/117849.htm
DOI: https://dx.doi.org/10.3748/wjg.117849

Yang J, Sai WL, Xia XX, Tang H, Xu M, Xie Q, Yao DF, Yao M. Differential metabolites facilitate metabolic dysfunction-associated fatty liver disease malignancy via immune evasion and M2-polarized macrophages. World J Gastroenterol 2026; 32(24): 117849 [DOI: 10.3748/wjg.117849]

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