Early recurrence risk stratification of hepatocellular carcinoma receiving preoperative radiotherapy: Incorporating clinical and imaging features across treatment phases

Table 3 Multivariable Cox regression analysis for early recurrence-free survival

Variables	Baseline model		Baseline-preoperative model		Preoperative model		Pre-postoperative model		Postoperative combined model
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Baseline variables
Cirrhosis	2.39 (0.84-6.77)	0.101	3.27 (1.09-9.83)	0.035	NA	NA	NA	NA	4.85 (1.59-14.74)	0.005
GGT > 60 U/L	3.31 (1.62-6.78)	0.001	4.29 (1.96-9.42)	< 0.001	NA	NA	NA	NA	4.67 (2.17-10.07)	< 0.001
Tumor size > 5 cm	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
APHE portion ≥ 50%	0.49 (0.25-0.96)	0.037	0.36 (0.18-0.72)	0.004	NA	NA	NA	NA	0.29 (0.14-0.59)	< 0.001
Preoperative variables
Preoperative AFP > 400 ng/mL	NA	NA	1.93 (0.82-4.52)	0.129	3.59 (1.63-7.94)	0.002	3.12 (1.38-7.04)	0.006	NA	NA
Preoperative CR by mRECIST	NA	NA	0.15 (0.05-0.45)	< 0.001	0.32 (0.11-0.91)	0.032	0.34 (0.12-0.97)	0.043	0.15 (0.05-0.45)	< 0.001
Pathological variables
MVI	NA	NA	NA	NA	NA	NA	1.77 (0.89-3.53)	0.102	2.36 (1.14-4.88)	0.021

HR: Hazard ratio; CI: Confidence interval; GGT: Gamma-glutamyl transpeptidase; APHE: Arterial phase hyperenhancement; AFP: Alpha-fetoprotein; CR: Complete response; mRECIST: Modified Response Evaluation Criteria in Solid Tumor; MVI: Microvascular invasion; NA: Not applicable.