Esmolol alleviates lipopolysaccharide-induced intestinal injuries by enhancing autophagy through the AMPK/mTOR/ULK1 pathway

doi:10.3748/wjg.v32.i23.117320

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 21, 2026; 32(23): 117320
Published online Jun 21, 2026. doi: 10.3748/wjg.v32.i23.117320

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Figure 5 Effects of lipopolysaccharide on autophagy changed with time in rats with sepsis. A: The expression of Beclin-1 and LC3-II in the intestine was detected by western blotting; B: Quantitative analysis of Beclin-1 protein expression at different time points; C: Quantitative analysis of LC3-II protein expression at different time points. Lipopolysaccharide (10 mg/kg) induced LC3-II at 3 hours (A and C) but inhibited Beclin-1 and LC3-II at 12 hours and 24 hours (A, B, and C). Data in the Sham group were set to 1. n = 6 in each group.

Citation: Zhang YB, Yu ZJ, Jin J, Liu MX, Ji FH, Yang XJ. Esmolol alleviates lipopolysaccharide-induced intestinal injuries by enhancing autophagy through the AMPK/mTOR/ULK1 pathway. World J Gastroenterol 2026; 32(23): 117320
URL: https://www.wjgnet.com/1007-9327/full/v32/i23/117320.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i23.117320

Zhang YB, Yu ZJ, Jin J, Liu MX, Ji FH, Yang XJ. Esmolol alleviates lipopolysaccharide-induced intestinal injuries by enhancing autophagy through the AMPK/mTOR/ULK1 pathway. World J Gastroenterol 2026; 32(23): 117320 [DOI: 10.3748/wjg.v32.i23.117320]

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