Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B

doi:10.3748/wjg.v32.i22.117500

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2026; 32(22): 117500
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.117500

Table 6 Abnormality rates of bone and renal safety indexes at the 96-week follow-up, n (%)

General information	TAF group (n = 45)	ETV group (n = 50)	Total (n = 95)	χ² value	P value
Prevalence of low bone mass	5 (11.1)	11 (22.0)	16 (16.8)	2.005	0.157
Blood urea abnormality rate	3 (6.7)	4 (8.0)	7 (7.4)	0.062	0.804
Serum creatinine abnormality rate	3 (6.7)	5 (10.0)	8 (8.4)	0.341	0.559
Serum retinol-binding protein abnormality rate	5 (11.1)	9 (18.0)	14 (14.7)	0.891	0.344
Serum cystatin C abnormality rate	6 (13.3)	11 (22.0)	17 (17.9)	1.211	0.271
Urinary α1-microglobulin abnormality rate	2 (4.4)	10 (20.0)	12 (12.6)	5.193	0.023
Urine N-acetyl-beta-D-glucosaminidase abnormality rate	3 (6.7)	12 (24.0)	15 (15.8)	5.352	0.021
Urine cystatin abnormality rate	2 (4.4)	9 (18.0)	11 (11.6)	4.251	0.039

TAF: Tenofovir alafenamide fumarate; ETV: Entecavir.

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Citation: Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500
URL: https://www.wjgnet.com/1007-9327/full/v32/i22/117500.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i22.117500

Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500 [DOI: 10.3748/wjg.v32.i22.117500]

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