Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B

doi:10.3748/wjg.v32.i22.117500

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2026; 32(22): 117500
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.117500

Table 4 Abnormality rates of bone and renal safety indexes at 48-week follow-up, n (%)

General information	TAF group (n = 45)	ETV group (n = 50)	Total (n = 95)	χ² value	P value
Prevalence of low bone mass	5 (11.1)	9 (18.0)	14 (14.7)	0.891	0.344
Blood urea abnormality rate	4 (8.9)	3 (6.0)	7 (7.4)	0.290	0.591
Serum creatinine abnormality rate	1 (2.2)	3 (6.0)	4 (4.2)	0.838	0.360
Serum retinol-binding protein abnormality rate	5 (11.1)	4 (8.0)	9 (9.5)	0.267	0.605
Serum cystatin C abnormality rate	7 (15.6)	5 (10.0)	12 (12.6)	0.662	0.416
Urinary α1-microglobulin abnormality rate	3 (6.7)	3 (6.0)	6 (6.3)	0.018	0.894
Urine N-acetyl-beta-D-glucosaminidase abnormality rate	7 (15.6)	6 (12.0)	13 (13.7)	0.254	0.615
Urine cystatin abnormality rate	3 (6.7)	8 (16.0)	11 (11.6)	2.015	0.156

TAF: Tenofovir alafenamide fumarate; ETV: Entecavir.

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Citation: Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500
URL: https://www.wjgnet.com/1007-9327/full/v32/i22/117500.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i22.117500

Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500 [DOI: 10.3748/wjg.v32.i22.117500]

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