Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B

doi:10.3748/wjg.v32.i22.117500

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 14, 2026; 32(22): 117500
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.117500

Table 2 Comparison of baseline index abnormality rates (n = 95), n (%)

General information	TAF group (n = 45)	ETV group (n = 50)	Total (n = 95)	χ² value	P value
ALT abnormality rate	10 (22.2)	7 (14.0)	17 (17.9)	1.090	0.297
Prevalence of low bone mass	5 (11.1)	9 (18.0)	14 (14.7)	0.895	0.344
Blood urea abnormality rate	2 (4.4)	0 (0.0)	2 (2.1)	2.270	0.132
Serum creatinine abnormality rate	5 (11.1)	9 (18.0)	14 (14.7)	0.895	0.344
Serum retinol-binding protein abnormality rate	7 (15.6)	9 (18.0)	16 (16.8)	0.101	0.751
Serum cystatin C abnormality rate	2 (4.4)	0 (0.0)	2 (2.1)	2.270	0.132
Urinary α1-microglobulin abnormality rate	7 (15.6)	5 (10.0)	12 (12.6)	0.662	0.416
Urine N-acetyl-beta-D-glucosaminidase abnormality rate	10 (22.2)	11 (22.0)	21 (22.1)	0.001	0.979
Urine cystatin abnormality rate	7 (15.6)	7 (14.0)	14 (14.7)	0.046	0.831

TAF: Tenofovir alafenamide fumarate; ETV: Entecavir; ALT: Alanine aminotransferase.

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Citation: Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500
URL: https://www.wjgnet.com/1007-9327/full/v32/i22/117500.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i22.117500

Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500 [DOI: 10.3748/wjg.v32.i22.117500]

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