Human epidermal growth factor receptor 2 in combined hepatocellular-cholangiocarcinoma: Prognostic and predictive guide for adjuvant chemotherapy

doi:10.3748/wjg.v32.i22.117417

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 14, 2026; 32(22): 117417
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.117417

Table 1 Univariate and multivariate analyses of prognostic factors based on overall survival

Variable	Univariate		Multivariate
Variable	HR (95%CI)	P value	HR (95%CI)	P value
Sex
Male	Reference
Female	1.329 (0.757-2.333)	0.322
Age	1.018 (0.986-1.050)	0.273
HBV
Present	Reference
Absent	1.222 (0.741-2.015)	0.433
Liver cirrhosis
Present	Reference
Absent	1.115 (0.678-1.834)	0.668
ALB (g/L)	0.980 (0.922-1.042)	0.520
TBIL (μmol/L)	1.003 (0.983-1.024)	0.780
PT (sec)	1.016 (0.775-1.332)	0.909
AFP (ng/mL)
≤ 40	Reference
> 40	1.192 (0.736-1.931)	0.475
CA19-9 (U/mL)
≤ 25	Reference		Reference
> 25	1.698 (1.015-2.838)	0.044^a	1.285 (0.720-2.294)	0.396
Histological grade
High/median	Reference		Reference
Low	2.469 (1.445-4.213)	0.001^a	2.313 (1.354-3.953)	0.002^a
Satellite lesions
Present	Reference
Absent	0.923 (0.503-1.694)	0.795
Microvascular invasion
Present	Reference		Reference
Absent	0.575 (0.290-1.141)	0.114^a	0.734 (0.326-1.655)	0.456
Macrovascular invasion
Present	Reference		Reference
Absent	0.513 (0.302-0.872)	0.014^a	0.586 (0.343-1.000)	0.050
Lymphatic node metastasis
Present	Reference		Reference
Absent	0.566 (0.279-1.148)	0.115	0.733 (0.321-1.670)	0.459
Maximum tumor diameter (cm)
≤ 5	Reference		Reference
> 5	1.684 (1.035-2.740)	0.036^a	1.159 (0.671-2.003)	0.596
HER2
Negative	Reference		Reference
Positive	0.482 (0.281-0.826)	0.008^a	0.551 (0.318-0.953)	0.033^a
TLS score
3	Reference		Reference
2	2.910 (1.036-8.170)	0.043^a	2.069 (0.695-6.160)	0.192
1	4.400 (1.542-12.550)	0.006^a	2.331 (0.675-8.048)	0.181
0	4.569 (1.763-11.841)	0.002^a	2.461 (0.820-7.391)	0.108

^aP < 0.05.

HR: Hazard ratio; CI: Confidence interval; CA19-9: Carbohydrate antigen 19-9; HER2: Human epidermal growth factor receptor 2; HBV: Hepatitis B virus; ALB: Albumin; TBIL: Total bilirubin; PT: Prothrombin time; AFP: Alpha-fetoprotein; TLS: Tertiary lymphoid structures.

Full Size Table

Citation: Han RY, Wei YK, Liu WN, Wang YM, Song TQ, Tian XD, Xia YR, Chen L, Gong WC. Human epidermal growth factor receptor 2 in combined hepatocellular-cholangiocarcinoma: Prognostic and predictive guide for adjuvant chemotherapy. World J Gastroenterol 2026; 32(22): 117417
URL: https://www.wjgnet.com/1007-9327/full/v32/i22/117417.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i22.117417

Han RY, Wei YK, Liu WN, Wang YM, Song TQ, Tian XD, Xia YR, Chen L, Gong WC. Human epidermal growth factor receptor 2 in combined hepatocellular-cholangiocarcinoma: Prognostic and predictive guide for adjuvant chemotherapy. World J Gastroenterol 2026; 32(22): 117417 [DOI: 10.3748/wjg.v32.i22.117417]

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