Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer

Figure 8 Tropomyosin 3 regulates gastric cancer cell progression through tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma in vivo. A and B: Tumor volumes and weights measured at the endpoint; C: Immunohistochemical analysis showed the expression of Ki-67 in xenograft tumor tissues from different groups; D: Hematoxylin and eosin staining analysis revealed the tumor tissues in different groups; E and F: Fresh lung tissues were harvested from mice intravenously injected with HGC27 cells through the tail vein, including the control group, tropomyosin 3 (TPM3) overexpression group, and TPM3 overexpression + tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma knockdown group. The number of lung metastatic nodules was then counted and hematoxylin and eosin staining was used to observe the lung metastatic nodules in different groups. Primary tumor samples were collected from mice injected with HGC27 cells, including the control group, TPM3 overexpression group, and TPM3 overexpression + tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma knockdown group. ^aP < 0.05, ^cP < 0.001, ^dP < 0.0001. NS: Not significant; TPM3: Tropomyosin 3; YWHAG: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Vector: Empty vector control.