Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer

Figure 4 Tropomyosin 3 enhances the mitogen-activated protein kinase signaling pathway in gastric cancer cells. A and B: Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses showed that tropomyosin 3 was involved in gastric cancer progression via the mitogen-activated protein kinase pathway; C: Western blotting analysis of tropomyosin 3 knockdown or overexpression effects on the mitogen-activated protein kinase pathway. Akt: Protein kinase B; BP: Biological process; CC: Cellular component; ERK: Extracellular signal-regulated kinase; GO: Gene Ontology; JAK: Janus kinase; JNK: C-Jun N-terminal kinase; KEGG: Kyoto Encyclopedia of Genes and Genomes; MAPK: Mitogen-activated protein kinase; MF: Molecular function; PI3K: Phosphoinositide 3-kinase; sh-NC: Control shRNA; STAT: Signal transducer and activator of transcription; TNF: Tumor necrosis factor; TPM3: Tropomyosin 3; Vector: Empty vector control.