Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer

Figure 2 Tropomyosin 3 promotes proliferation, migration and invasion of gastric cancer cells. A: Validation of tropomyosin 3 (TPM3) knockdown and overexpression efficiency; B-D: Cell counting kit-8 assay, colony formation assay, and 5-ethynyl-2-deoxyuridine assay were conducted to evaluate the effect of TPM3 knockdown or overexpression on the proliferative capacity of gastric cancer cells; E and F: Transwell assay and wound healing assay were performed to assess the impact of TPM3 knockdown or overexpression on the migration and invasion ability of gastric cancer cells. ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. EdU: 5-ethynyl-2-deoxyuridine; sh-NC: Control shRNA; TPM3: Tropomyosin 3; Vector: Empty vector control.