Mechanism of anti-human antigen D (HuD/ELAVL4) autoantibody-induced enteric neuronal apoptosis in irritable bowel syndrome and its potential for targeted intervention

Figure 6 mRNA expression of the downstream targets of HuD in rat ileum and colon. A: Special AT-rich sequence-binding protein 1; B: Nerve growth factor; C: Brain-derived neurotrophic factor; D: Neurotrophic factor-3; E: Growth-associated protein-43; F: Neuroserpin. Data are expressed as mean ± SD. One-way analysis of variance with Tukey’s multiple comparison test was performed and n = 3. ^aP < 0.05, ^bP < 0.01, and ^dP < 0.0001. SATB1: Special AT-rich sequence-binding protein 1; NGF: Nerve growth factor; BDNF: Brain-derived neurotrophic factor; NT-3: Neurotrophic factor-3; GAP-43: Growth-associated protein-43.