Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis

doi:10.3748/wjg.v32.i22.116469

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 14, 2026; 32(22): 116469
Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.116469

Table 2 Sensitivity analysis on proton pump inhibitor use and risk of inflammatory bowel disease

Study omitted	OR	95%CI
Study omitted	OR	Lower limit	Upper limit
Räisänen et al[25], 2023	1.71	1.01	2.88
Onwuzo et al[19], 2023	1.40	0.98	1.98
Abrahami et al[13], 2023	2.17	1.35	3.49
Schwartz et al[24], 2019	1.70	0.99	2.94
Xia et al[14], 2021	2.14	1.07	4.30

OR: Odds ratio; CI: Confidential interval.

Full Size Table

Citation: Gao M, Yin RR, Mao X, Shao ZX, Shi YY. Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(22): 116469
URL: https://www.wjgnet.com/1007-9327/full/v32/i22/116469.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i22.116469

Gao M, Yin RR, Mao X, Shao ZX, Shi YY. Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(22): 116469 [DOI: 10.3748/wjg.v32.i22.116469]

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